Regulatory T cells in autoimmune hepatitis: an updated overview.
Regulatory T cells in autoimmune hepatitis: an updated overview.
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DOI：
10.1016/j.jaut.2021.102619
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发表时间：
2021-05
影响因子：
12.8
通讯作者：
Vergani D
中科院分区：
文献类型：
--
作者：
Longhi MS;Mieli-Vergani G;Vergani D
调节性T细胞（Tcells）是通过防止对自身抗原的免疫应答来维持免疫稳态的关键参与者。Treg频率和/或功能的缺陷导致参与自身免疫攻击的压倒性CD 4和CD 8 T细胞免疫应答。自身免疫损伤的持续也受到Treg倾向的支持，以在暴露于促炎性攻击后获得效应细胞特征。Treg损伤在自身免疫性肝病（即自身免疫性肝炎、原发性胆汁性胆管炎和原发性硬化性胆管炎）的发生和持续中起允许作用。在这篇综述中，我们概述了研究报告的作用，Treg损伤的发病机制，这些条件和讨论的方法来恢复Treg的数量和功能，无论是在试管中的生成/扩增或通过在体内扩增后，管理低剂量IL-2。这些潜在的治疗策略的挑战和警告也进行了审查和讨论。
Regulatory T-cells (Tregs) are key players in the maintenance of immune homeostasis by preventing immune responses to self-antigens. Defects in Treg frequency and/or function result in overwhelming CD4 and CD8 T cell immune responses participating in the autoimmune attack. Perpetuation of autoimmune damage is also favored by Treg predisposition to acquire effector cell features upon exposure to a proinflammatory challenge. Treg impairment plays a permissive role in the initiation and perpetuation of autoimmune liver diseases, namely autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. In this Review, we outline studies reporting the role of Treg impairment in the pathogenesis of these conditions and discuss methods to restore Treg number and function either by generation/expansion in the test tube or through in vivo expansion upon administration of low dose IL-2. Challenges and caveats of these potential therapeutic strategies are also reviewed and discussed.