Contribution of Neuroepigenetics to Huntington's Disease.
Contribution of Neuroepigenetics to Huntington's Disease.
复制标题
神经毛皮物质对亨廷顿氏病的贡献。
DOI：
10.3389/fnhum.2017.00017
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发表时间：
2017
影响因子：
2.9
通讯作者：
Merienne K
中科院分区：
文献类型：
--
作者：
Francelle L;Lotz C;Outeiro T;Brouillet E;Merienne K
不平衡的表观遗传调控被认为有助于几种神经退行性疾病的进展，包括亨廷顿氏病（HD），一种被认为是表观遗传失调范例的遗传疾病。在这篇综述中，我们试图根据神经表观遗传学的最新进展，解决有关表观遗传变化在HD中的作用的开放性问题。我们特别讨论了使用全基因组规模方法的研究，这些方法提供了对正常和病变神经元（包括HD神经元）中表观遗传调控、基因表达和神经元活动之间关系的见解。我们建议细胞类型特异性技术和基于3d的方法将在神经退行性疾病脑区域易感性的背景下推进表观基因组的知识。为了设计比目前基于组蛋白去乙酰化酶（HDAC）抑制剂更有效的治疗策略，需要更好地了解表观遗传变化的机制及其在神经退行性疾病中的后果。HD的研究可能在这一过程中起到推动作用。
Unbalanced epigenetic regulation is thought to contribute to the progression of several neurodegenerative diseases, including Huntington’s disease (HD), a genetic disorder considered as a paradigm of epigenetic dysregulation. In this review, we attempt to address open questions regarding the role of epigenetic changes in HD, in the light of recent advances in neuroepigenetics. We particularly discuss studies using genome-wide scale approaches that provide insights into the relationship between epigenetic regulations, gene expression and neuronal activity in normal and diseased neurons, including HD neurons. We propose that cell-type specific techniques and 3D-based methods will advance knowledge of epigenome in the context of brain region vulnerability in neurodegenerative diseases. A better understanding of the mechanisms underlying epigenetic changes and of their consequences in neurodegenerative diseases is required to design therapeutic strategies more effective than current strategies based on histone deacetylase (HDAC) inhibitors. Researches in HD may play a driving role in this process.