Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma
Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma
复制标题
活化的细胞外信号调节激酶1/2与唾液腺腺样囊性癌肺转移的关系。
DOI：
10.3892/or_00000200
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发表时间：
2009-01-01
期刊：
影响因子：
4.2
通讯作者：
Yu, Guang-Yan
中科院分区：
文献类型：
--
作者：
Hu, Kai;Gan, Ye-Hua;Yu, Guang-Yan
肺转移是涎腺腺样囊性癌的重要特征之一。细胞外信号调节激酶1/2（extracellular signal-regulated kinase 1/2，ERK 1/2）通路的激活可能与某些恶性肿瘤的进展有关，但其在SACC肺转移中的作用尚不清楚。我们检测了高转移率SACC-LM和低转移率SACC-83中活化ERK 1/2的表达，以及SACC患者肺转移组和非转移组的组织中活化ERK 1/2的表达。Western blot分析表明SACC-LM比SACC-83具有更高的活化ERK 1/2的表达。免疫组化结果显示，73%（8/11）的SACC有肺转移，而25%（3/12）的SACC无肺转移（P < 0.05）。
Lung metastasis is one of the important characteristics of salivary adenoid cystic carcinoma (SACC). Although activation of extracellular signal-regulated kinase 1/2 (ERK 1/2) pathway may be associated with cancer progression in some malignant tumors, its roles in lung metastasis of SACC remains unclear. We examined the expression of activated ERK1/2 in SACC-LM with high king-metastatic rate and SACC-83 with low king-metastatic rate, as well as in the tissues from lung-metastatic and non-metastatic groups of SACC patients. Western blot analysis indicated that SACC-LM exhibited higher expression of activated ERK1/2 than SACC-83. Similarly, immunohistochemistry showed that expression of activated ERK1/2 was detected in 73% (8/11) of the primary tissues from SACC patients with lung metastasis, while only 25% (3/12) of the primary tissues from SACC patients without lung metastasis (P