Time-lag estimate between dietary intake and breast cancer mortality in Japan.
Time-lag estimate between dietary intake and breast cancer mortality in Japan.
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DOI：
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发表时间：
2007
影响因子：
1.3
通讯作者：
E. Harashima;Y. Nakagawa;G. Urata;K. Tsuji;M. Shirataka;Y. Matsumura
中科院分区：
文献类型：
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作者：
E. Harashima;Y. Nakagawa;G. Urata;K. Tsuji;M. Shirataka;Y. Matsumura
这项研究考察了1948年至2000年期间日本女性的营养素摄入量，包括总膳食纤维(TDF)和脂肪，与年龄调整的乳腺癌死亡率(MBC)之间的关系。女性MBC的信息是基于《日本生命统计》的数据。营养数据收集自国家营养调查报告。对数据进行了皮尔逊相关和偏相关分析，调整了生殖因素的影响。通过测量0-35年死亡率延迟建立的线性关系的强度来估计时间滞后，并通过比较相关系数进行统计评估。偏相关分析表明，个体总脂肪(r=0.688)、动物蛋白(r=0.657)、碳水化合物(r=-0.886)和植物蛋白(r=-0.770)的摄入量与微生物量呈显著正相关。这些相关系数都随着时间滞后的增加而变化并达到最大值。脂肪、动物蛋白和TDF影响的估计时滞值分别为20~32年、19~31年和9~35年。结果表明，日本女性MBC的增加与摄入西方典型的高脂肪、高动物蛋白和低纤维饮食的长期影响有关。
This study examines the relationship between the nutrient intake, including total dietary fiber (TDF) and fat, and the age-adjusted mortality from breast cancer (MBC) in Japanese females during the period from 1948 to 2000. The information for MBC in females was based on the data in Vital Statistics of Japan. Nutritional data were collected from the National Nutrition Survey reports. The data were analyzed by Pearson's correlation and a partial correlation, adjusting for the effect of reproductive factors. The time lag was estimated by measuring the strength of the linear relationship set up for a 0-35-year delay in mortality and statistically evaluated by comparing the correlation coefficients. The partial correlation analysis indicated that the individual intakes of total fat (r=0.688), animal protein (r=0.657), carbohydrate (r=-0.886), and plant protein (r=-0.770) were significantly (p<0.01) correlated with MBC. Each of these coefficients of correlation changed and reached a maximum value with increasing time lag. The estimated time lag values for the influence of fat, animal protein and TDF were 20-32 years, 19-31 years and 9-35 years, respectively. It is deduced from the results that the increased MBC in Japanese women is related to the long-term effect from the intake of a high-fat, high-animal protein and low-fiber diet typical in the western world.