EARLY CHANGES IN FOVEAL THICKNESS IN EYES WITH CENTRAL SEROUS CHORIORETINOPATHY
EARLY CHANGES IN FOVEAL THICKNESS IN EYES WITH CENTRAL SEROUS CHORIORETINOPATHY
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DOI：
10.1097/iae.0b013e31826710a0
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发表时间：
2013-02-01
影响因子：
3.3
通讯作者：
Kurimoto, Yasuo
中科院分区：
文献类型：
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作者：
Hata, Masayuki;Oishi, Akio;Kurimoto, Yasuo
目的：为探讨中心性浆液性脉络膜视网膜病变（central serous chorioretinopathy，CERD）中心凹变薄发生的时间和速度，对60例（60只眼）活动性CERD患者的外核层（Outer nuclear layer，ONL）厚度进行了测量。根据症状持续时间将患者分为3组：1个月内（A组，25只眼），1至6个月（B组，17只眼）和>6个月（C组，18只眼）。比较各组间的外核层厚度和视力。结果：ONL厚度与病程相关（R =-0.61，P < 0.001）。C组视力较A组差（P = 0.003）。各组和健康对侧眼的ONL平均厚度分别为82.4、70.2、53.5和89.3 μ m。各组间比较有统计学意义。A组17只眼在首次访视后3 ~ 6个月复查。ONL平均厚度从81.9 μ m下降到75.0 μ m（P = 0.020）。结论：中心性浆液性脉络膜视网膜病变ONL变薄始于早期，只要视网膜下液持续存在，ONL变薄就可能持续。视网膜33：296-301，2013
Purpose: To investigate when and how fast the foveal thinning occurs in central serous chorioretinopathy.Methods: Outer nuclear layer (ONL) thickness was measured in 60 eyes of 60 patients with active central serous chorioretinopathy. Patients were divided into 3 groups based on the duration of symptoms; within 1 month (Group A, 25 eyes), 1 to 6 months (Group B, 17 eyes), and >6 months (Group C, 18 eyes). Outer nuclear layer thickness and visual acuity were compared between each group. Some of the patients underwent several examinations and serial changes were analyzed.Results: The ONL thickness was correlated with the duration of symptoms (R = -0.61, P < 0.001). Visual acuity was worse in Group C compared with Group A (P = 0.003). The mean ONL thickness of each group and healthy contralateral eyes was 82.4, 70.2, 53.5, and 89.3 mu m, respectively. Comparisons between each group showed statistical significances. Seventeen eyes in Group A were re-examined between 3 and 6 months after the first visit. The mean ONL thickness significantly decreased from 81.9 mu m to 75.0 mu m (P = 0.020).Conclusion: In central serous chorioretinopathy, ONL thinning starts in the early stage and may continue as long as the subretinal fluid persists. RETINA 33:296-301, 2013