Chronic antidepressant administration fails to attenuate apomorphine-induced decreases in rat striatal dopamine metabolites.
Chronic antidepressant administration fails to attenuate apomorphine-induced decreases in rat striatal dopamine metabolites.
复制标题
长期服用抗抑郁药不能减弱阿扑吗啡引起的大鼠纹状体多巴胺代谢物的减少。
DOI：
10.1016/0014-2999(84)90617-4
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发表时间：
1984
影响因子：
5
通讯作者：
W. Buckett
中科院分区：
文献类型：
--
作者：
G. Diggory;W. Buckett
The responsiveness of the rat striatal dopamine (DA) receptor system to apomorphine (APO) was assessed after 10 days of antidepressant administration. Desipramine (DMI), dothiepin (DOTH), iprindole (IPR) and nomifensine (NOM) were administered intra-peritoneally, twice daily, to rats for 10 days and 42 h after the last drug dose, animals were injected with APO (25 or 200 μg/kg s.c., 15 min) or vehicle. Striatal content of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), assayed using a recently developed high-performance liquid chromatography-electrochemical detection (HPLC-ECD) method, showed that prolonged administration of all four antidepressant drugs failed to modify the effect of APO on DA metabolism. The results of these experiments therefore do not provide evidence to support the suggestion that subsensitivity in presynaptic DA ‘autoreceptors’ is a significant biochemical correlate of chronic antidepressant drug administration.
纹状体多巴胺自身受体不受长期服用抗抑郁药的影响。
影响因子：
5
作者：
Holcomb,HH;Bannon,MJ;Roth,RH
通讯作者：
Roth,RH
长期抗抑郁药治疗会降低螺哌啶醇标记的血清素受体结合。
DOI：
10.1126/science.6251550
发表时间：
1980
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Peroutka,SJ;Snyder,SH
通讯作者：
Snyder,SH