Comparison of Brain Temperature Distribution in Mathematical and Solid Models of Head Thermal Characteristics
Comparison of Brain Temperature Distribution in Mathematical and Solid Models of Head Thermal Characteristics
复制标题
头部热特性数学模型和实体模型中脑部温度分布的比较
DOI：
10.1002/eej.22642
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发表时间：
2015
影响因子：
0.4
通讯作者：
Minami Ito
中科院分区：
文献类型：
--
作者：
Yutaka Takagi;S. Honma;H. Wakamatsu;Minami Ito
在低温治疗过程中，精确控制脑组织的温度是必要的，以防止继发性脑损伤和避免各种副作用。因此，在基础水平上研究了低温治疗中脑内温度分布的可视化。为此目的，使用虚拟现实技术来创建数学模型，该数学模型反映大脑中的代谢产热和傅立叶热传导，具有基于各种临床模型的必要参数。在本研究中，开发了一个实验系统，通过使用基于MRI数据的大脑形状的硅橡胶构建的固体大脑模型来检查人头部中的血液流动的数学模拟，考虑到由三个薄膜加热器发出的代谢热，并包括六个传感器用于测量局部大脑温度。数学模拟描述了具有与大脑实体模型相似结构的大脑中的内部温度分布。利用脑实体模型进行的数学模拟和实验结果在稳态下是相当一致的，包括区域温度的控制。这允许在类似于活体的条件下进行热传导实验，其中内部温度在临床上难以观察。因此，数学模拟被证实是有用的，与实验一起使用的实体模型，为未来的脑低温治疗的研究。
Accurate temperature control of brain tissue during hypothermia treatment is necessary in order to prevent secondary brain damage and to avoid various side effects. Thus, the visualization of the intracerebral temperature distribution in hypothermia treatment was studied at the fundamental level. For this purpose a virtual reality technology was used to create a mathematical model that reflects metabolic heat production and Fourier heat conduction in a brain with the necessary parameters based on various clinical models. In the present study, an experimental system was developed to examine a mathematical simulation of the blood flow in a human head by using a solid brain model constructed using silicon rubber in the shape of a brain based on MRI data, taking into account the metabolic heat given off by three film heaters and including six sensors for the measurement of regional brain temperature. The mathematical simulation describes the internal temperature distribution in a brain with a similar structure to the brain solid model. The results of mathematical simulations and experiments using the brain solid model were quite consistent in the steady state, including control of regional temperature. This allows for the performance of heat conduction experiments under conditions similar to those of a living body, in which the internal temperature is clinically difficult to observe. Thus, the mathematical simulation is confirmed to be useful together with experiments using the solid model for the study of future brain hypothermia treatment.