Phage Therapy in Bacterial Infections Treatment: One Hundred Years After the Discovery of Bacteriophages.
Phage Therapy in Bacterial Infections Treatment: One Hundred Years After the Discovery of Bacteriophages.
复制标题
细菌感染治疗中的噬菌体疗法：发现噬菌体一百年后。
DOI：
10.1007/s00284-016-1166-x
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发表时间：
2017-02
影响因子：
2.6
通讯作者：
Wyżewski Z
中科院分区：
文献类型：
--
作者：
Cisek AA;Dąbrowska I;Gregorczyk KP;Wyżewski Z
在过去的几年里，噬菌体的治疗用途重新受到开花的关注。这种逆转是由于细菌的耐药菌株的治疗难度增加。细菌对抗生素的耐药性是当代医学中的一个严重问题，但并不涉及对噬菌体裂解机制的耐药性。裂解性噬菌体能够在噬菌体感染周期结束时杀死抗药性细菌。因此，噬菌体疗法的发展是一种潜在的改善细菌感染治疗的方法。然而，有抗菌噬菌体治疗的困难指定扩大知识的噬菌体的性质和对宿主的影响。实验表明，先天性免疫和适应性免疫都参与了机体对病毒的清除。抗真菌的免疫反应与给药途径有关，并可能因细菌病毒类型而异。因此，测试每一个噬菌体的免疫应答是非常重要的，特别是如果正在考虑静脉内治疗。前几年缺乏这些数据是噬菌体疗法被放弃的原因之一，尽管它已经进行了长达一个世纪的研究。最近的研究成果使我们期待着噬菌体治疗，可以在更大范围内应用，并随后将其付诸实践。
The therapeutic use of bacteriophages has seen a renewal of interest blossom in the last few years. This reversion is due to increased difficulties in the treatment of antibiotic-resistant strains of bacteria. Bacterial resistance to antibiotics, a serious problem in contemporary medicine, does not implicate resistance to phage lysis mechanisms. Lytic bacteriophages are able to kill antibiotic-resistant bacteria at the end of the phage infection cycle. Thus, the development of phage therapy is potentially a way to improve the treatment of bacterial infections. However, there are antibacterial phage therapy difficulties specified by broadening the knowledge of the phage nature and influence on the host. It has been shown during experiments that both innate and adaptive immunity are involved in the clearance of phages from the body. Immunological reactions against phages are related to the route of administration and may vary depending on the type of bacterial viruses. For that reason, it is very important to test the immunological response of every single phage, particularly if intravenous therapy is being considered. The lack of these data in previous years was one of the reasons for phage therapy abandonment despite its century-long study. Promising results of recent research led us to look forward to a phage therapy that can be applied on a larger scale and subsequently put it into practice.