BRENDA, the enzyme database: updates and major new developments
BRENDA, the enzyme database: updates and major new developments
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DOI：
10.1093/nar/gkh081
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Schomburg, D
中科院分区：
文献类型：
--
作者：
Schomburg, I;Chang, A;Schomburg, D
BRENDA（BRaunschweig ENzyme Database）代表了基于原始文献的酶和代谢信息的全面集合。该数据库包含来自 9800 种不同生物体的至少 83000 种不同酶的数据，按类似于 4200 个 EC 编号进行分类。 BRENDA 包括有关分类和命名、反应和特异性、功能参数、发生、酶结构、应用、工程、稳定性、疾病、分离和制备、链接和文献参考的生化和分子信息。这些数据是从类似 46 000 篇参考文献中提取和评估的，只要在 PubMed 中引用了该参考文献，这些参考文献就会链接到 PubMed。在过去的一年里，BRENDA 经历了重大变化，包括更新速度的大幅提高，超过 50% 的数据在 2002 年或 2003 年上半年更新，开发了新的 EC 树浏览器、分类树浏览器、配体结构的化学子结构搜索引擎、受控词汇的开发、一些信息领域的本体和配体名称的同义词库。学术界可以通过 http://www.brenda 免费访问该数据库。 uni-koeln.de。
BRENDA (BRaunschweig ENzyme DAtabase) represents a comprehensive collection of enzyme and metabolic information, based on primary literature. The database contains data from at least 83 000 different enzymes from 9800 different organisms, classified in similar to 4200 EC numbers. BRENDA includes biochemical and molecular information on classification and nomenclature, reaction and specificity, functional parameters, occurrence, enzyme structure, application, engineering, stability, disease, isolation and preparation, links and literature references. The data are extracted and evaluated from similar to 46 000 references, which are linked to PubMed as long as the reference is cited in PubMed. In the past year BRENDA has undergone major changes including a large increase in updating speed with >50% of all data updated in 2002 or in the first half of 2003, the development of a new EC-tree browser, a taxonomy-tree browser, a chemical substructure search engine for ligand structure, the development of controlled vocabulary, an ontology for some information fields and a thesaurus for ligand names. The database is accessible free of charge to the academic community at http://www.brenda. uni-koeln.de.