The mechanisms of action of reproductive toxins.
The mechanisms of action of reproductive toxins.
复制标题
生殖毒素的作用机制。
DOI：
10.1002/ajim.1983.4.1-2.65
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发表时间：
1983
影响因子：
3.5
通讯作者：
D. Mattison
中科院分区：
文献类型：
--
作者：
D. Mattison
对生殖毒素的作用机制进行了一般性讨论。生殖毒物可能通过多种机制之一产生不良影响。一些异生素可能通过化学反应性（例如烷化剂破坏卵母细胞）或通过与内源性分子的结构相似性（例如激素拮抗剂）直接发挥作用。其他异生物质通过代谢加工成直接作用的毒物（例如，激素原或代谢激活反应中间体）或通过改变内分泌稳态（例如，增加类固醇清除率）来间接中断生殖过程。列出了通过一种或多种这些机制证明生殖毒性的化合物的选定实例，并附有生殖毒素的广泛参考书目。
A general discussion of the mechanisms of action of reproductive toxins is presented. Reproductive toxicants may produce their adverse effects by one of several mechanisms. Some xenobiotics may act directly, either by virtue of chemical reactivity (eg, oocyte destruction by alkylating agents) or by structural similarity to endogenous molecules (eg, hormone antagonists). Other xenobiotics interrupt reproductive processes indirectly either by metabolic processing to a direct-acting toxicant (eg, prohormone or metabolic activation to reactive intermediate) or by altering endocrine homeostasis (eg, increased steroid clearance). Selected examples of compounds demonstrating reproductive toxicity by one or more of these mechanisms are tabulated and an extensive bibliography of reproductive toxins is attached.