Association of CYP24A1 gene polymorphism with colorectal cancer in the Jiamusi population.
Association of CYP24A1 gene polymorphism with colorectal cancer in the Jiamusi population.
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佳木斯人群CYP24A1基因多态性与结直肠癌的相关性
DOI：
10.1371/journal.pone.0253474
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Chai L;Ni J;Ni X;Zhang N;Liu Y;Ji Z;Zhao X;Zhu X;Zhao B;Xin G;Wang Y;Yang F;Sun L;Zhu X;Bao W;Shui X;Wang F;Chen F;Yang Z
佳木斯市是我国结直肠癌发病率最高的地区。居民中发生这种情况的遗传因素尚不清楚。鉴于寒冷季节长，人们穿更多的衣服，减少紫外线照射，我们的目的是研究维生素D代谢相关基因CYP 24 A1多态性与CRC易感性之间的关联。方法采用病例对照研究方法，选择168例结直肠癌患者和710例健康体检者作为对照组。寻找合理的易感变异，并进行临床表型-基因型关联分析。结果总体而言，CYP 24 A1的两种多态性rs6013905 AX（P = 0.02，OR = 1.89，95%CI：1.09-3.29）和rs 2762939 GX（P = 0.02，OR = 1.52，95%CI：1.08-2.13）与佳木斯人群中的CRC显著相关。在女性组中，CYP 24 A1的三个多态性rs6013905 AX（P = 0.04，OR = 2.59，95%CI：1.03-6.49），rs2762939 GX（P = 0.01，OR = 2.35，95%CI：1.25-4.42）和rs6068816 GG（P = 0.05，OR = 1.89，95%CI：0.99-3.59）携带者与CRC显著相关。在临床表型-基因型分析中，rs6013905 GG（P = 0.05，OR = 4.00，95%CI：0.92-17.48）和rs2762939 GX（P = 0.03，OR = 4.87，95%CI：1.00-23.69）携带者与低分化CRC显著相关，而CYP 24 A1 rs6068816 AX与肿瘤类型显著相关（P = 0.02，OR = 2.08，95%CI：1.10-3.96）和位置（P = 0.04，OR = 2.24，95%CI：1.05-4.77）。结论CYP 24 A1基因多态性可能是佳木斯地区结直肠癌高发的遗传危险因素。具有CYP 24 A1基因多态性的个体可能增加了维生素D吸收的障碍，从而增加了CRC发展的风险。
Background The population in Jiamusi has been reported to have the highest prevalence of colorectal cancer (CRC) in China. The genetic causal-effect for this occurrence among the residents remains unclear. Given the long cold seasons with people wearing more clothes and reduced UV exposure, we aimed to study the association between the vitamin D metabolism-related gene CYP24A1 polymorphism and CRC susceptibility. Method A case-control study was conducted that included 168 patients with CRC and 710 age-matched healthy individuals as the control group. Plausible susceptible variations were sought and clinical phenotypic-genotype association analysis was performed. Results Overall, two CYP24A1 polymorphisms, rs6013905 AX (P = 0.02, OR = 1.89, 95%CI: 1.09–3.29) and rs2762939 GX (P = 0.02, OR = 1.52, 95%CI: 1.08–2.13) were significantly associated with CRC in the Jiamusi population. In the female group, three CYP24A1 polymorphisms, rs6013905 AX (P = 0.04, OR = 2.59, 95%CI: 1.03–6.49), rs2762939 GX (P = 0.01, OR = 2.35, 95%CI: 1.25–4.42), and rs6068816 GG (P = 0.05, OR = 1.89, 95%CI: 0.99–3.59) carriers were significantly associated with CRC. In clinical phenotypic-genotype analysis, rs6013905 GG (P = 0.05, OR = 4.00, 95%CI: 0.92–17.48) and rs2762939 GX (P = 0.03, OR = 4.87, 95%CI: 1.00–23.69) carriers were significantly associated with poorly differentiated CRC, while CYP24A1 rs6068816 AX was significantly associated with the tumor type (P = 0.02, OR = 2.08, 95%CI: 1.10–3.96) and location (P = 0.04, OR = 2.24, 95%CI: 1.05–4.77). Conclusion CYP24A1 gene polymorphism may be a genetic risk factor attributable to the highest prevalence of CRC in Jiamusi people. Individuals with CYP24A1 gene polymorphism may have an increased barrier for vitamin D absorption, thus contributing to the risk of CRC development.
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影响因子：
2.3
作者：
Kelly, Jennifer L.;Drake, Matthew T.;Fredericksen, Zachary S.;Asmann, Yan W.;Liebow, Mark;Shanafelt, Tait D.;Feldman, Andrew L.;Ansell, Stephen M.;Macon, William R.;Herr, Megan M.;Wang, Alice H.;Nowakowski, Grzegorz S.;Call, Timothy G.;Habermann, Thomas M.;Slager, Susan L.;Witzig, Thomas E.;Cerhan, James R.
通讯作者：
Cerhan, James R.
影响因子：
8.4
作者：
Jonsson, Bengt;Hofmarcher, Thomas;Wilking, Nils
通讯作者：
Wilking, Nils
影响因子：
3.2
作者：
Horvath, Henrik C.;Lakatos, Peter;Kallay, Enikoe
通讯作者：
Kallay, Enikoe
影响因子：
5.6
作者：
Wu X;Cheng J;Yang K
通讯作者：
Yang K
DOI：
10.1161/atvbaha.110.211805
发表时间：
2010-12
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Shen H;Bielak LF;Ferguson JF;Streeten EA;Yerges-Armstrong LM;Liu J;Post W;O'Connell JR;Hixson JE;Kardia SL;Sun YV;Jhun MA;Wang X;Mehta NN;Li M;Koller DL;Hakonarson H;Keating BJ;Rader DJ;Shuldiner AR;Peyser PA;Reilly MP;Mitchell BD
通讯作者：
Mitchell BD