Pharmacokinetic study of selective continuous internal carotid CDDP infusion in malignant brain tumors.
Pharmacokinetic study of selective continuous internal carotid CDDP infusion in malignant brain tumors.
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选择性连续颈内动脉CDDP输注治疗恶性脑肿瘤的药代动力学研究。
DOI：
10.2176/nmc.31.695
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发表时间：
1991
影响因子：
1.9
通讯作者：
T. Noguchi
中科院分区：
文献类型：
--
作者：
Y. Seiki;I. Shibata;H. Terao;M. Kudo;T. Noguchi
顺式二胺二氯铂（CDDP）经颈动脉选择性连续输注治疗9例恶性脑肿瘤患者，其中5例为胶质母细胞瘤，1例为混合胶质瘤，3例为转移性肿瘤。除1例胶质母细胞瘤患者使用较低的10 mg/hr剂量外，所有病例均通过导管以100 mg/hr剂量在颈内动脉内输注CDDP。CDDP浓度测定结果显示：1)血液中CDDP在输注终止时达到峰值，随后缓慢下降；2)CDDP浸润肿瘤内囊肿并在肿瘤内积累；3)脑脊液中CDDP在输注后6 ~ 18 h达到峰值；4)肿瘤/血浆CDDP比值在2 ~ 8之间变化。9例中有3例肿瘤大小适度缩小，但未达到完全缓解。在肿瘤组织中观察到CDDP引起的组织学改变，而在正常脑实质中没有。
Cis-diamminedichloroplatinum (CDDP) was administered by selective continuous internal carotid infusion to nine patients with malignant brain tumors, including five glioblastomas, one mixed glioma, and three metastatic tumors. CDDP was infused through a catheter in the internal carotid artery at 100 mg/hr in all cases, except one glioblastoma case in which the lower rate of 10 mg/hr was used. The results of CDDP concentration measurements were: 1) CDDP in the blood peaked at termination of CDDP infusion and then decreased slowly, 2) CDDP infiltrated intratumoral cysts and accumulated there, 3) CDDP in the cerebrospinal fluid peaked 6-18 hours after infusion, and 4) the tumor/plasma CDDP ratio varied from 2 to 8. The size of tumors decreased moderately in three of the nine cases, but no complete response was achieved. The histological changes due to CDDP were observed in the tumor tissue and were absent in the normal brain parenchyma.
PCNU 和复发性儿童脑肿瘤。
影响因子：
3.9
作者：
Allen,JC;Hancock,C;Walker,R;Tan,C
通讯作者：
Tan,C