Pre-stroke use of beta-blockers does not affect ischaemic stroke severity and outcome
Pre-stroke use of beta-blockers does not affect ischaemic stroke severity and outcome
复制标题
DOI：
10.1111/j.1468-1331.2011.03475.x
复制
发表时间：
2012-02-01
影响因子：
5.1
通讯作者：
De Keyser, J.
中科院分区：
文献类型：
--
作者：
De Raedt, S.;Haentjens, P.;De Keyser, J.
背景和目的：目前尚不清楚卒中前使用β受体阻滞剂是否会影响卒中结局。本研究评估中风前使用β-受体阻滞剂对缺血性中风的严重程度和3个月的功能outcome.Methods的独立效果：中风前使用β-受体阻滞剂进行了调查，在1375缺血性中风患者谁已被列入两个安慰剂对照试验与卢贝鲁唑。采用美国国立卫生研究院卒中量表（NIHSS）或欧洲卒中量表（ESS）评估卒中严重程度。使用3个月时改良的兰金量表（mRS）评分>3作为功能结局不良的衡量标准。结果：264名患者在中风发作前接受了β受体阻滞剂治疗，105名患者在中风后继续接受治疗。β受体阻滞剂预治疗不影响基线卒中严重程度。未使用者与使用选择性β 1受体阻滞剂或非选择性β受体阻滞剂者之间的卒中严重程度没有差异。中风前β受体阻滞剂的使用或β受体阻滞剂的使用前，并继续中风onset.Conclusions：中风前使用β受体阻滞剂的可能性不影响在3个月的中风严重程度和功能的结果。
Background and purpose: It is unclear whether pre-stroke beta-blockers use may influence stroke outcome. This study evaluates the independent effect of pre-stroke use of beta-blockers on ischaemic stroke severity and 3 months functional outcome.Methods: Pre-stroke use of beta-blockers was investigated in 1375 ischaemic stroke patients who had been included in two placebo-controlled trials with lubeluzole. Stroke severity was assessed by either the National Institute of Health Stroke Scale (NIHSS) or the European Stroke Scale (ESS). A modified Rankin scale (mRS) score of >3 at 3 months was used as measure for the poor functional outcome.Results: Two hundred and sixty four patients were on beta-blockers prior to stroke onset, and 105 patients continued treatment after their stroke. Pretreatment with beta-blockers did not influence baseline stroke severity. There was no difference in stroke severity between nonusers and those on either a selective beta(1)-blocker or a nonselective beta-blocker. The likelihood of a poor outcome at 3 months was not influenced by pre-stroke beta-blocker use or beta-blocker use before and continued after stroke onset.Conclusions: Pre-stroke use of beta-blockers does not appear to influence stroke severity and functional outcome at 3 months.