Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside.
Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside.
复制标题
阿糖胞苷连续静脉和皮下输注的药代动力学。
DOI：
10.1182/blood.v59.6.1351.bloodjournal5961351
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发表时间：
1982
期刊：
影响因子：
20.3
通讯作者：
S. Sallan
中科院分区：
文献类型：
--
作者：
H. Weinstein;T. Griffin;J. Feeney;H. Cohen;R. Propper;S. Sallan
比较了连续皮下注射阿糖胞苷（ara-C）与连续静脉注射的药代动力学。两种给药途径的稳态血清阿糖胞苷水平和骨髓抑制相似。CSF/血清ara-C比值范围为0.14至0.91（平均值为0.58）。阿糖胞苷持续皮下输注是静脉输注的一种方便可靠的替代方法。
The pharmacokinetics of continuous subcutaneous cytosine arabinoside (ara-C) infusions were compared with continuous intravenous infusions. Steady-state serum ara-C levels and myelosuppression were similar with both routes of administration. CSF/serum ara-C ratios ranged from 0.14 to 0.91 (mean, 0.58). Continuous subcutaneous ara-C infusions were a convenient and reliable alternative to intravenous infusions.