Clinical presentation, case management and outcomes for the first 32 COVID-19 patients in Nigeria
Clinical presentation, case management and outcomes for the first 32 COVID-19 patients in Nigeria
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DOI：
10.11604/pamj.2020.35.2.23262
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发表时间：
2020-04-01
影响因子：
1.2
通讯作者：
Osibogun, Akin
中科院分区：
文献类型：
--
作者：
Bowale, Abimbola;Abayomi, Akin;Osibogun, Akin
导言：成功遏制大流行冠状病毒病(新冠肺炎)在很大程度上取决于对人群中病例的流行病学和临床概况以及病例管理方法的正确了解。本研究记录了尼日利亚首批32名新冠肺炎患者的表现特征、治疗方式和结果。方法：本研究采用了2020年2月27日至4月6日在尼日利亚西南部拉各斯州大陆医院收治和出院的前32名患者的医疗记录。结果：患者平均年龄38.1岁(SD：15.5)，其中66%为男性。四分之三(75%)的患者病情中等严重，而16%的患者没有症状。最常见的症状是发热(59%)和干咳(44%)。从阳性结果到入院的平均时间为1.63天(SD：1.31)。几乎所有(97%)的患者都接受了洛比那韦-利托那韦治疗，没有记录的死亡。中位住院天数为12天(智商：9~13.5)。结论：在对尼日利亚首例新冠肺炎病例的初步分析中，临床表现轻至中度，无死亡病例。尼日利亚需要采取措施提高入院的及时性和减少住院时间，以加强对新冠肺炎的反应。
Introduction: success in curtailing the pandemic coronavirus disease (COVID-19) depends largely on a sound understanding of the epidemiologic and clinical profile of cases in a population as well as the case management approach. This study documents the presenting characteristics, treatment modalities and outcomes of the first 32 COVID-19 patients in Nigeria.Methods: this retrospective study used medical records of the first 32 patients admitted and discharged from the Mainland Hospital, Lagos State, southwest Nigeria between February 27 and April 6, 2020. The outcomes of interest were death, promptness of admission process and duration of hospitalization.Results: the mean age of the patients was 38.1 years (SD: 15.5) and 66% were male. Three-quarters (75%) of the patients presented in moderately severe condition while 16% were asymptomatic. The most common presenting symptoms were fever (59%) and dry cough (44%). The mean time between a positive test result and admission was 1.63 days (SD: 1.31). Almost all (97%) the patients were treated with lopinavir-ritonavir with no recorded death. The median duration of hospital stay was 12 days (IQR: 9-13.5).Conclusion: in this preliminary analysis of the first COVID-19 cases in Nigeria, clinical presentation was mild to moderate with no mortality. Processes to improve promptness of admission and reduce hospital stay are required to enhance the response to COVID-19 in Nigeria.