Promising effects of oxytocin on social and food-related behaviour in young children with Prader-Willi syndrome: a randomized, double-blind, controlled crossover trial
Promising effects of oxytocin on social and food-related behaviour in young children with Prader-Willi syndrome: a randomized, double-blind, controlled crossover trial
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DOI：
10.1111/cen.13169
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发表时间：
2016-12-01
影响因子：
3.2
通讯作者：
Hokken-Koelega, A. C. S.
中科院分区：
文献类型：
--
作者：
Kuppens, R. J.;Donze, S. H.;Hokken-Koelega, A. C. S.
研究背景Prader-Willi综合征（PWS）是一种以进食过多、饱食感减退、易发脾气、操纵和控制行为及强迫症为特征的特殊行为表型。PWS与下丘脑和催产素能功能障碍有关。在没有PWS的人中，鼻内催产素给药对社交和饮食行为以及体重平衡具有积极作用。在荷兰PWS参考中心进行的交叉研究。方法每日两次鼻内催产素交叉干预（剂量范围24-48 IU/天）和安慰剂给药，均持续4周，25例PWS儿童结果在总的组中，没有发现催产素对社会行为或食欲过盛的显著影响，但在17名11岁以下的儿童中，与安慰剂相比，催产素治疗期间，父母报告的愤怒（P = 0.001）、悲伤（P = 0.005）、冲突（P = 0.010）和食物相关行为（P = 0.011）以及社会行为改善（P = 0.018）显著减少。在8名11岁以上的儿童中，与安慰剂相比，催产素治疗对幸福（P = 0039）、愤怒（P = 0042）和悲伤（P = 0042）项目产生了负面影响。有没有副作用或不良事件。ConclusionsThis随机，双盲，安慰剂对照研究表明，鼻内催产素给药的社会行为和食物相关的行为在PWS小于11岁的儿童有有益的影响，但不是在那些年龄大于11岁。
BackgroundPrader-Willi syndrome (PWS) is known for hyperphagia with impaired satiety and a specific behavioural phenotype with stubbornness, temper tantrums, manipulative and controlling behaviour and obsessive-compulsive features. PWS is associated with hypothalamic and oxytocinergic dysfunction. In humans without PWS, intranasal oxytocin administration had positive effects on social and eating behaviour, and weight balance.Objective and hypothesesTo evaluate the effects of intranasal oxytocin compared to placebo administration on social behaviour and hyperphagia in children with PWS.DesignRandomized, double-blind, placebo-controlled, crossover study in a PWS Reference Center in the Netherlands.MethodCrossover intervention with twice daily intranasal oxytocin (dose range 24-48 IU/day) and placebo administration, both during 4 weeks, in 25 children with PWS (aged 6 to 14 years).ResultsIn the total group, no significant effects of oxytocin on social behaviour or hyperphagia were found, but in the 17 children younger than 11 years, parents reported significantly less anger (P = 0001), sadness (P = 0005), conflicts (P = 0010) and food-related behaviour (P = 0011), and improvement of social behaviour (P = 0018) during oxytocin treatment compared with placebo. In the eight children older than 11 years, the items happiness (P = 0039), anger (P = 0042) and sadness (P = 0042) were negatively influenced by oxytocin treatment compared to placebo. There were no side effects or adverse events.ConclusionsThis randomized, double-blind, placebo-controlled study suggests that intranasal oxytocin administration has beneficial effects on social behaviour and food-related behaviour in children with PWS younger than 11 years of age, but not in those older than 11 years of age.