Deficits in reciprocal social behavior in male twins: Evidence for a genetically independent domain of psychopathology
Deficits in reciprocal social behavior in male twins: Evidence for a genetically independent domain of psychopathology
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DOI：
10.1097/01.chi.0000046811.95464.21
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发表时间：
2003-04-01
影响因子：
13.3
通讯作者：
Todd, RD
中科院分区：
文献类型：
--
作者：
Constantino, JN;Hudziak, JJ;Todd, RD
目的：先前的研究已经证明遗传对许多儿童精神疾病（包括自闭症）有重大影响。在这项研究中，作者试图量化遗传对互惠社会行为缺陷（广泛性发育障碍的一个定义特征）的影响与遗传对儿童其他行为领域的影响的共同程度。方法：对 219 对男性双胞胎的流行病学样本完成了儿童行为检查表 (CBCL) 和社会反应量表 (SRS)。 SRS（以前称为社会互惠量表）是一种社交障碍衡量标准，可将患有自闭症谱系障碍的儿童与患有其他儿童精神疾病的儿童区分开来。结果：回归分析表明 CBCL 综合征占 SRS 评分方差的 43%。双变量分析显示，SRS 评分部分受到 CBCL 社会问题综合征表型的影响。然而，SRS 评分的 44% 因果影响独立于 CBCL 综合征，并且本质上是遗传的（90% 置信区间：0.38-0.49）。结论：这些结果支持人群中互惠社会行为缺陷存在连续分布，这些缺陷在遗传上基本上独立于儿童精神病理学的其他领域。
Objective: Previous studies have demonstrated substantial genetic influences on many child psychiatric disorders, including autism. In this study the authors attempted to quantify the degree to which genetic influences on deficits in reciprocal social behavior (a defining feature of pervasive developmental disorders) are shared with genetic influences on other domains of behavior in children. Method: Child Behavior Checklists (CBCL) and Social Responsiveness Scales (SRS) were completed for an epidemiological sample of 219 pairs of male twins. The SRS (formerly known as the Social Reciprocity Scale) is a measure of social impairment that distinguishes children with autism spectrum disorders from those with other child psychiatric disorders. Results: Regression analysis indicated that CBCL syndromes account for 43% of the variance in SRS scores. Bivariate analyses revealed that SRS scores are affected, in part, by phenotypic influences from the CBCL Social Problem syndrome. Forty-four percent of the causal influences on SRS scores, however, are independent from those on CBCL syndromes and are genetic in nature (90% confidence interval: 0.38-0.49). Conclusion: These results support the existence of a continuous distribution of deficits in reciprocal social behavior in the population, which are substantially genetically independent from other domains of child psychopathology.