Memory for emotional events:: differential effects of centrally versus peripherally acting β-blocking agents
Memory for emotional events:: differential effects of centrally versus peripherally acting β-blocking agents
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DOI：
10.1007/s002130050675
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发表时间：
1998-08-01
影响因子：
3.4
通讯作者：
Gooren, LJG
中科院分区：
文献类型：
--
作者：
van Stegeren, AH;Everaerd, W;Gooren, LJG
来自动物研究的大量证据表明，与情感体验相关的增强记忆涉及β-肾上腺素能系统的激活。这一假设得到了人类受试者的进一步支持，即用普萘洛尔阻断β-肾上腺素能受体选择性地降低了对情感事件的记忆。在本研究中，我们比较了普萘洛尔（一种易于穿过血脑屏障的脂溶性药物）与纳多洛尔（一种穿过血脑屏障的水溶性药物）的作用，以确定其作用是否涉及外周或中枢β-肾上腺素能受体。tors.这些药物的效果，在受试者观看幻灯片之前服用，这些幻灯片要么是情绪激动的，要么是相对中性的内容，一周后通过惊喜记忆测试进行测试。与先前的结果一致，普萘洛尔损害了那些观看情绪版幻灯片的受试者的记忆（回忆和识别）。相比之下，纳多洛尔并没有损害情绪幻灯片的记忆。这些结果表明，阻断中枢β-肾上腺素能受体是负责减少存储的情绪事件。结果支持这样的观点，即轻度情绪事件的记忆涉及中枢的激活，但不一定是外周的β-肾上腺素能受体。
Substantial evidence from animal research indicates that enhanced memory associated with emotional experiences involves activation of the beta-adrenergic system. This hypothesis is further supported by the finding in human subjects that blockade of beta-adrenergic receptors with propranolol selectively reduced memory for emotional events. In the present study, we compared the effects of propranolol, a lipid soluble drug which crosses the blood-brain barrier easily, with those of nadolol, a water soluble drug which crosses the blood-brain barrier to a considerably lesser extent, to determine whether the effect involved peripheral or central beta-adrenergic receptors. tors. The effects of these drugs, taken before subjects watched a slide show that was either emotionally arousing or relatively neutral in content, were tested 1 week later with a surprise memory test. Consistent with previous results, propranolol impaired memory (recall and recognition) in the subjects who saw the emotional version of the slide show. In contrast, nadolol did not impair memory of the emotional slide show. These results indicate that the blockade of central beta-adrenergic receptors is responsible for the reduction in storage of emotional events. The results support the view that memory of a mild emotional event involves activation of central, but not necessarily peripheral beta-adrenergic receptors.