Ligand-receptor interactions in plant hormone signaling.
Ligand-receptor interactions in plant hormone signaling.
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DOI：
10.1111/tpj.15115
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发表时间：
2020-12
期刊：
影响因子：
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通讯作者：
J. Takeuchi;Kosuke Fukui;Yoshiya Seto;Yousuke Takaoka;Masanori Okamoto
中科院分区：
文献类型：
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作者：
J. Takeuchi;Kosuke Fukui;Yoshiya Seto;Yousuke Takaoka;Masanori Okamoto
小分子植物激素主要控制植物的生长、发育、分化和环境响应。在被子植物中普遍存在9种植物激素，近20年来，通过对具有遗传突变体的模式植物的基因组解码，已阐明了它们激素作用的分子机制。特别是激素受体的发现，极大地促进了对信号转导系统的理解。通过X射线晶体结构分析，已经确定了9种激素中的8种的配体-受体复合物的三维结构，并且已经在原子水平上揭示了配体感知机制。集体研究已经揭示了植物激素的分子功能，它们作为分子胶或受体激活的变构调节剂。在这篇综述中，我们介绍了各自的激素信号转导的概述，并描述了配体-受体相互作用的结构基础。
Small-molecule plant hormones principally control plant growth, development, differentiation, and environmental responses. Nine types of plant hormones are ubiquitous in angiosperms, and the molecular mechanisms of their hormone actions have been elucidated during the last two decades by genomic decoding of model plants with genetic mutants. In particular, the discovery of hormone receptors has greatly contributed to the understanding of signal transduction systems. The three-dimensional structure of the ligand-receptor complex has been determined for eight of the nine hormones by X-ray crystal structure analysis, and ligand perception mechanisms have been revealed at the atomic level. Collective research has revealed the molecular function of plant hormones that act as either molecular glue or an allosteric regulator for activation of receptors. In this review, we introduce an overview of the respective hormone signal transduction and describe the structural bases of ligand-receptor interactions.