Reorganization of synaptic inputs to spinal dorsal horn neurons in neuropathic pain
Reorganization of synaptic inputs to spinal dorsal horn neurons in neuropathic pain
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DOI：
10.1080/00207454.2021.1873980
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发表时间：
2021-01
影响因子：
2.2
通讯作者：
R. Terayama;Kenta Uchibe
中科院分区：
文献类型：
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作者：
R. Terayama;Kenta Uchibe
摘要周围神经损伤后，受损轴突的中枢终末部位以及受损的初级传入纤维会产生各种负性的结构和功能变化。这种变化已被证明参与神经性疼痛的发展，包括异常疼痛感觉，如异常性疼痛和痛觉过敏。由于脊髓背角是外周感觉神经信号传递的第一中枢部位，并在外周神经损伤或外周组织慢性炎症后表现出多种变化，因此它是神经病理性疼痛发生机制中最重要的部位之一。周围神经损伤后脊髓背角抑制性中间神经元的功能中断和胶质细胞活化导致神经元回路的重组和二级神经元兴奋性的变化。这些事件参与神经性疼痛的发展或维持。在这里，我们描述了初级传入，中间神经元和胶质细胞的相互作用，可能会导致周围神经损伤后脊髓背角神经元的突触输入重组。
Abstract Peripheral nerve injuries produce a variety of negative structural and functional changes in the central terminal sites of damaged axons, as well as the injured primary afferents. Such changes have been shown to be involved in the development of neuropathic pain, which includes abnormal pain sensations such as allodynia and hyperalgesia. Since the spinal dorsal horn is the first central site where signals from peripheral sensory nerves are transmitted and shows a variety of changes after peripheral nerve injury or chronic inflammation of peripheral tissues, it is one of the most important sites contributing to the mechanisms underlying the development of neuropathic pain. The functional disruption of inhibitory interneurons and glial activation in the spinal dorsal horn after peripheral nerve injury cause reorganization of neuronal circuits and changes in the excitability of second-order neurons. These events are involved in the development or maintenance of neuropathic pain. Here, we describe the interactions of primary afferents, interneurons, and glial cells that may cause reorganization of synaptic inputs to spinal dorsal horn neurons after peripheral nerve injury.