Emergence of dengue virus type 4 genotype IIA in Malaysia
Emergence of dengue virus type 4 genotype IIA in Malaysia
复制标题
DOI：
10.1099/0022-1317-83-10-2437
复制
发表时间：
2002-10-01
影响因子：
3.8
通讯作者：
Chan, YF
中科院分区：
文献类型：
--
作者：
AbuBakar, S;Wong, PF;Chan, YF
对最近分离的5株4型登革病毒(DENV-4)包膜(E)基因序列的系统发育分析表明，马来西亚出现了独特的地理和时间上的DENV-4亚型IIA。其中4个分离株与印度尼西亚4型登革热病毒1973有直系血统，并显示出与另一株新近分离的4型登革热病毒MYO1-22713在血清型内重组的证据。分离株MYO1-22713的E基因有较早重组的证据，包括1976年印度尼西亚登革热病毒4型和1969年马来西亚1型登革热病毒。这些结果表明，来自独立祖先谱系的DENV-4之间的血清型内重组可能是导致马来西亚出现DENV-4亚型IIA的原因。
Phylogenetic analyses of the envelope (E) gene sequence of five recently isolated dengue virus type 4 (DENV-4) suggested the emergence of a distinct geographical and temporal DENV-4 subgenotype IIA in Malaysia. Four of the isolates had direct ancestral lineage with DENV-4 Indonesia 197 3 and showed evidence of intra-serotypic recombination with the other recently isolated DENV-4, MYO1-22713. The E gene of isolate MYO1-22713 had strong evidence of an earlier recombination involving DENV-4 genotype II Indonesia 1976 and genotype I Malaysia 1969. These results suggest that intra-serotypic recombination amongst DENV-4 from independent ancestral lineages may have contributed to the emergence of DENV-4 subgenotype IIA in Malaysia.