CORTICAL PENICILLIN FOCUS AS A GENERATOR OF REPETITIVE SPIKE-TRIGGERED WAVES OF SPREADING DEPRESSION IN RATS
CORTICAL PENICILLIN FOCUS AS A GENERATOR OF REPETITIVE SPIKE-TRIGGERED WAVES OF SPREADING DEPRESSION IN RATS
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DOI：
10.1007/bf00237205
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发表时间：
1983-01-01
影响因子：
2
通讯作者：
BURES, J
中科院分区：
文献类型：
--
作者：
KOROLEVA, VI;BURES, J
在戊巴比妥钠麻醉的大鼠(n=66)暴露的顶叶皮质上应用钠青霉素钠建立癫痫灶。在发作间期放电短暂(30s)自发中断后出现的棘波，有时伴随着棘波触发的扩散性抑制(STSD)波，从而阻断病灶的活动几分钟。第一个恢复峰诱发了另一次STSD，重复的STSD产生持续了20个周期，平均周期为6min。STSD在电刺激病灶或对称性脑区诱发的后遗症后更有规律地出现，也可由局灶外皮质区微量注射5%KCl所诱发的SD波诱发。当对侧大脑半球的另一个青霉素病灶在相对SD不稳定期间开始触发局灶性放电时，正在进行的STSD循环被中断。42%的动物出现STSD波。发作间期放电率较低(10次/分钟)时，有70%的患者尝试诱发STSD成功，但较高放电率(30次/分钟)时，大多数尝试失败。STSD可能是当孤立的癫痫棘波出现在清除性降低的水平时产生的，而重复的STSD是由局灶性放电和扩散性抑制之间的突触和代谢调节的相互作用产生的。
Epileptic foci were established by application of Na-penicillin on the exposed parietal cortex of rats (n = 66) anesthetized with pentobarbital. Spikes appearing after a brief (> 30s) spontaneous interruption of the interictal discharge were sometimes followed by a spike-triggered spreading depression (STSD) wave, which blocked the activity of the focus for several min. The 1st recovering spike induced another STSD and repetitive STSD generation continued for up to 20 cycles, with a median cycle duration of 6 min. STSD appeared more regularly after postictal depression induced by electrical stimulation of the focus or of the symmetrical brain area, and could also be elicited by SD waves evoked by microinjection of 5% KCl into extrafocal cortical regions. An ongoing STSD cycle was interrupted when another penicillin focus in the contralateral hemisphere started to trigger the focal discharge during relative SD refractoriness. STSD waves were observed in 42% of the animals. Attempts to elicit STSD were successful in 70% when the interictal discharge rate was low (< 10/min) but mostly failed with higher discharge rates (> 30/min). STSD is probably generated when an isolated epileptic spike appears at the level of decreased clearance and repetitive STSD are produced by synaptically and metabolically mediated interaction between focal discharge and spreading depression.