Evidence of chromosome regions and gene involvement in inflammatory breast cancer
Evidence of chromosome regions and gene involvement in inflammatory breast cancer
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DOI：
10.1002/ijc.10729
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发表时间：
2002-12-20
影响因子：
6.4
通讯作者：
Lidereau, R
中科院分区：
文献类型：
--
作者：
Lerebours, F;Bertheau, P;Lidereau, R
炎症性乳腺癌（IBC）是一种罕见但具有侵袭性的原发性乳腺癌。与非炎症性乳腺癌（非IBC）相比，IBC的分子改变鲜为人知。我们假设这些变化的种类和频率可能在IBC和非IBC之间有所不同，并解释了其特殊的侵袭性。我们通过分析66例IBC患者的71个微卫星标记，研究了与原发性乳腺癌相关的等位基因丢失（染色体臂1p、3p、6p、6q、7q、8p、9p、11p、11q、16q、17p和17q）。杂合性缺失（LOH）较为常见，平均分数等位基因缺失（FAL）指数为52%。与已发表的非IBC数据相比，等位基因丢失在3p21-p14、6p、8p22、11q、13q14和17q21位点尤为频繁，这表明在IBC中存在显著改变的基因。相比之下，通过实时定量PCR测量的ERBB2、MYC和CCND1的DNA扩增水平在IBC和非IBC之间没有差异。(C) 2002 Wiley-Liss, Inc。
Inflammatory breast cancer (IBC) is a rare but particularly aggressive form of primary breast cancer. In contrast to noninflammatory breast cancer (non IBC), the molecular alterations underlying IBC are poorly known. We postulated that the kind and frequency of these alterations might differ between IBC and non IBC and account for its particular aggressiveness. We investigated allelic losses associated with primary breast cancer (on chromosome arms 1p, 3 p, 6p, 6q, 7q, 8p, 9p, 11p, 11q, 16q, 17p and 17q) by analyzing 71 microsatellite markers in 66 cases of IBC. Loss of heterozygosity (LOH) was frequent, with a mean fractional allelic loss (FAL) index of 52%. Relative to published data on non IBC, allelic loss was particularly frequent at 3p21-p14, 6p, 8p22, 11q, 13q14 and 17q21, suggesting the presence of genes that are markedly altered in IBC. In contrast, the DNA amplification levels of ERBB2, MYC and CCND1, as measured by real-time quantitative PCR, did not differ between IBC and non IBC. (C) 2002 Wiley-Liss, Inc.