Does White Wine Qualify for French Paradox? Comparison of the Cardioprotective Effects of Red and White Wines and Their Constituents: Resveratrol, Tyrosol, and Hydroxytyrosol (Retracted article. See vol. 60, pg. 2767, 2012)
Does White Wine Qualify for French Paradox? Comparison of the Cardioprotective Effects of Red and White Wines and Their Constituents: Resveratrol, Tyrosol, and Hydroxytyrosol (Retracted article. See vol. 60, pg. 2767, 2012)
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DOI：
10.1021/jf801791d
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发表时间：
2008-10-22
影响因子：
6.1
通讯作者：
Das, Dipak K.
中科院分区：
文献类型：
--
作者：
Dudley, Jocelyn I.;Lekli, Istvan;Das, Dipak K.
人们普遍认为，法国人的悖论与红葡萄酒的消费有关，而不是其他品种的葡萄酒，包括白色葡萄酒或香槟。最近的一些研究表明，白色葡萄酒也可以像红葡萄酒一样保护心脏。本研究比较了红葡萄酒、白色葡萄酒及其主要心脏保护成分的心脏保护能力。不同组的大鼠分别灌胃红葡萄酒、白色葡萄酒、白藜芦醇、酪醇和羟基酪醇。红葡萄酒及其成分白藜芦醇和白色葡萄酒及其成分酪醇和羟基酪醇都表现出不同程度的心脏保护作用，这通过它们改善缺血后心室性能、减少心肌梗死面积和心肌细胞凋亡以及减少过氧化物形成的能力来证明。在这项研究中发现，虽然每种葡萄酒及其组分都增加了线粒体复合物（I-IV）和柠檬酸合酶的酶活性，这些酶在氧化磷酸化和ATP合成中起着非常重要的作用，但与其他组相比，其中一些组在诱导活性方面更具复合物特异性。通过增加磷酸化Akt、Bcl-2、eNOS、NOS、考克斯-1、考克斯-2、Trx-1、Trx-2和HO-1的表达进一步证实了细胞保护能力。这项研究的结果表明，白色葡萄酒可以提供类似于红葡萄酒的心脏保护，如果它富含酪醇和羟基酪醇。
It is generally believed that the French paradox is related to the consumption of red wine and not other varieties of wine, including white wine or champagne. Some recent studies have indicated that white wine could also be as cardioprotective as red wine. The present investigation compares the cardioprotective abilities of red wine, white wine, and their principal cardioprotective constituents. Different groups of rats were gavaged with red wine, white wine, resveratrol, tyrosol, and hydroxytyrosol. Red wine and its constituent resveratrol and white wine and its constituents tyrosol and hydroxytyrosol all showed different degrees of cardioprotection as evidenced by their abilities to improve postischemic ventricular performance, reduce myocardial infarct size and cardiomyocyte apoptosis, and reduce peroxide formation. It was discovered in this study that although each of the wines and their components increased the enzymatic activities of the mitochondrial complex (I-IV) and citrate synthase, which play very important roles in oxidative phosphorylation and ATP synthesis, some of the groups were more complex-specific in inducing the activity compared to the other groups. Cardioprotective ability was further confirmed by increased expression of phospho-Akt, Bcl-2, eNOS, NOS, COX-1, COX-2, Trx-1, Trx-2, and HO-1. The results of this study suggest that white wine can provide cardioprotection similar to red wine if it is rich in tyrosol and hydroxytyrosol.