Successful treatment of refractory cancer pain with morphine and ropivacaine: A case report.
Successful treatment of refractory cancer pain with morphine and ropivacaine: A case report.
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吗啡和罗哌卡因成功治疗难治性癌痛
DOI：
10.1097/md.0000000000007052
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发表时间：
2017-06
期刊：
影响因子：
1.6
通讯作者：
Ni J
中科院分区：
文献类型：
--
作者：
Li H;Yang L;Guo Z;Tang Y;Chen N;Lu Y;Ni J
疼痛是癌症患者经历的最常见和最痛苦的症状之一。癌症疼痛是一种复杂的现象，涉及生理、心理、社会和认知领域。虽然阿片类药物仍然是癌症疼痛管理的基石，但它们并不是对所有患者都有效。该病例强调了使用罗哌卡因输注和随后快速减少阿片类药物剂量成功治疗阿片类药物难治性重度癌症疼痛危象。这份报告说明了罗哌卡因用于癌症疼痛。一名62岁的男性转移性肺癌患者因无法控制的胸背部和腹部疼痛入院。患者被诊断为顽固性癌痛。吗啡和罗哌卡因的成功治疗，以获得更长的阿片类药物难治性重度癌痛。术后1、3和6个月时，疼痛缓解70-75%，整体活动改善。术后随访6个月，镇痛效果稳定。随访期间未报告并发症。我们的报告表明，罗哌卡因是成功的治疗癌症疼痛在这种情况下。它将为我们提供一个新的导航癌症疼痛治疗。同时，这一发现仍需要进一步的研究来证实。
Pain is one of the most common and distressing symptoms experienced by cancer patients. Cancer pain is a complex phenomenon with physical, psychological, social, and cognitive domains. Although opioids remain a cornerstone of cancer pain management, they are not effective in all patients. This case highlights the successful treatment of an opioid-refractory severe cancer pain crisis with ropivacaine infusion and subsequent rapid tapering of opioid dose. This report illustrates the use of ropivacaine for cancer pain. A 62-year-old man with metastatic lung cancer was admitted to the hospital with uncontrolled chest-back and abdominal pain. The patient was diagnosed as refractory cancer pain. Successful treatment with morphine and ropivacaine was performed to obtain longer opioid refractory severe cancer pain. At 1, 3, and 6 months postoperative review, 70-75% relief of pain was achieved with overall activity was improved. The analgesic effect was stable during the 6-month follow-up period. No complications were reported during the follow-up period. Our report demonstrates that ropivacaine is successful treatment for cancer pain in this case. It will supply us a novel navigation in cancer pain treatments. Meanwhile, this finding still needs additional study for confirmation.