Decreased Plasma Levels of Granulocyte-Colony Stimulating Factor (G-CSF) in Patients with Early Alzheimer's Disease
Decreased Plasma Levels of Granulocyte-Colony Stimulating Factor (G-CSF) in Patients with Early Alzheimer's Disease
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DOI：
10.3233/jad-2009-1017
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发表时间：
2009-01-01
影响因子：
4
通讯作者：
Gawaz, Meinrad
中科院分区：
文献类型：
--
作者：
Laske, Christoph;Stellos, Konstantinos;Gawaz, Meinrad
阿尔茨海默病（AD）的特点是大脑中大量神经元细胞丢失。粒细胞集落刺激因子（G-CSF）是一种造血生长因子，可促进神经保护作用并支持脑内神经发生。在本研究中，我们发现50例早期AD患者的G-CSF血浆水平明显低于50例年龄匹配的健康对照。在AD患者中，G-CSF水平与脑脊液中淀粉样蛋白- β (a β(1-42))水平呈显著负相关，但与脑脊液中tau蛋白水平或Mini-Mental Status Examination评分无显著负相关。此外，在AD患者和健康对照中，G-CSF血浆水平与年龄呈显著负相关。综上所述，早期AD患者G-CSF血浆水平降低可能导致造血脑支持不足，并与推定的致病相关。需要进一步的研究来检验是否调节造血生长因子如G-CSF可能是一种有希望的治疗AD的新策略。
Alzheimer's disease (AD) is characterized by massive neuronal cell loss in the brain. Granulocyte-colony stimulating factor (G-CSF) is a hematopoietic growth factor that promotes neuroprotective effects and supports neurogenesis in the brain. In the present study, we found significantly lower G-CSF plasma levels in 50 early AD patients in comparison with 50 age-matched healthy controls. In AD patients, G-CSF levels showed a significant inverse correlation with amyloid-beta (A beta(1-42)) levels in cerebrospinal fluid, but not with levels of tau protein in cerebrospinal fluid or Mini-Mental Status Examination scores. In addition, G-CSF plasma levels were significantly inversely correlated with age in AD patients and healthy controls. In conclusion, decreased G-CSF plasma levels in early AD patients may contribute to a deficient hematopoietic brain support with putative pathogenic relevance. Further studies are needed to examine whether a modulation of hematopoietic growth factors such as G-CSF could be a promising new therapeutic strategy for AD.