Implication of Ferroptosis in Cholangiocarcinoma: A Potential Future Target?
Implication of Ferroptosis in Cholangiocarcinoma: A Potential Future Target?
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DOI：
10.2147/cmar.s406150
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发表时间：
2023
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
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作者：
胆管癌（CCA）是第二常见的肝脏肿瘤，其总体5年生存率低于10%。更深入地了解导致CCA进展的分子发病机制对于开发更好的治疗方法来管理这种疾病至关重要。铁凋亡是一种氧化性铁依赖性的细胞死亡，据报道与肿瘤的发生和发展有关。特别是，在胆管癌发生和CCA发展中常见的铁凋亡和炎症可能与疾病进展一致。值得注意的是，癌细胞的关键特征是“铁成瘾”，这对于癌发生和癌症进展中的高代谢需求至关重要。此外，铁代谢在铁缺乏症中非常重要。此外，癌细胞易受铁凋亡的影响可能是CCA发生的一个可能机制。虽然铁下垂如何与CCA发展有关的潜在机制需要进一步研究，但开发一种新的策略与促铁下垂治疗相结合将是未来令人兴奋的CCA治疗方法。
Cholangiocarcinoma (CCA), the second most common liver neoplasm, has a poor overall 5-year survival rate of less than 10%. A deeper understanding of the molecular pathogenesis contributing to CCA progression is essential for developing better therapeutic approaches to manage this disease. Ferroptosis, an oxidative iron-dependent form of regulated cell death, has been reported to be involved in tumorigenesis and progression. In particular, ferroptosis and inflammation, which are common issues in cholangiocarcinogenesis and CCA development, might be in concert with disease progression. Notably, the key feature of cancer cells is “iron addiction”, which is crucial for the high metabolic demand in carcinogenesis and cancer progression. Additionally, iron metabolism is of great importance in ferroptosis. Moreover, that cancer cells are vulnerable to ferroptosis might be a possible mechanism of CCA development. Although the underlying mechanism of how ferroptosis is implicated in CCA development requires further investigation, developing a new strategy combined with a pro-ferroptotic treatment would be an exciting CCA treatment approach in the future.