Pediatric lung transplantation as standard of care
Pediatric lung transplantation as standard of care
复制标题
小儿肺移植作为护理标准
DOI：
10.1111/ctr.14126
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发表时间：
2020
影响因子：
2.1
通讯作者：
C. Benden
中科院分区：
文献类型：
--
作者：
R. Werner;C. Benden
对于患有进行性晚期肺病的婴儿、儿童和青少年，肺移植是最终的治疗选择。幸运的是，近年来儿童肺移植后的结局有所改善，现在产生了良好的长期结局，不低于成人肺移植。儿科肺移植领域发展迅速;因此，本文旨在更新重要问题，如移植转诊和评估，以及作为“移植桥梁”的体外生命支持。鉴于供体器官的持续缺乏限制了小儿肺移植的成功，本文讨论了供体的可接受性标准和肺移植物缩小的手术选择。移植后，免疫抑制对于预防同种异体移植物排斥反应至关重要;然而，关于免疫抑制的循证数据很少。药物相关的副作用是常见的，密切的治疗药物监测是高度建议与个性化的患者方法。慢性肺移植物功能障碍（CLAD）仍然是儿科肺移植的致命弱点，限制了其长期成功。不幸的是，CLAD的治疗选择仍然受到限制。进行性CLAD的最后一种选择是考虑肺再移植;然而，接受肺再移植的儿科患者数量非常少，其成功高度依赖于最合适候选人的最佳选择。
For infants, children, and adolescents with progressive advanced lung disease, lung transplantation represents the ultimate therapy option. Fortunately, outcomes after pediatric lung transplantation have improved in recent years now producing good long‐term outcomes, no less than comparable to adult lung transplantation. The field of pediatric lung transplantation has rapidly advanced; thus, this review aims to update on important issues such as transplant referral and assessment, and extra‐corporal life support as “bridge to transplantation”. In view of the ongoing lack of donor organs limiting the success of pediatric lung transplantation, donor acceptability criteria and surgical options of lung allograft size reduction are discussed. Post‐transplant, immunosuppression is vital for prevention of allograft rejection; however, evidence‐based data on immunosuppression are scarce. Drug‐related side effects are frequent, close therapeutic drug monitoring is highly advised with an individually tailored patient approach. Chronic lung allograft dysfunction (CLAD) remains the Achilles' heel of pediatric lung transplant limiting its long‐term success. Unfortunately, therapy options for CLAD are still restricted. The last option for progressive CLAD would be consideration for lung re‐transplant; however, numbers of pediatric patients undergoing lung re‐transplantation are very small and its success depends highly on the optimal selection of the most suitable candidate.
影响因子：
8.9
作者：
Hayes, Don, Jr.;Cherikh, Wida S.;Stehlik, Josef
通讯作者：
Stehlik, Josef
闭塞性细支气管炎综合征并非小儿肺移植中闭塞性细支气管炎的特异性。
DOI：
10.1016/j.healun.2014.10.004
发表时间：
2015
期刊：
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
影响因子：
--
作者：
Towe,Christopher;ChesterOgborn,A;Ferkol,Thomas;Sweet,Stuart;Huddleston,Charles;White,Frances;Faro,Albert
通讯作者：
Faro,Albert
肺移植治疗囊性纤维化。
影响因子：
3.3
作者：
Liou,TheodoreG;Woo,MarlynS;Cahill,BarbaraC
通讯作者：
Cahill,BarbaraC