Spatial organization based reciprocal switching of enzyme-free nucleic acid circuits
Spatial organization based reciprocal switching of enzyme-free nucleic acid circuits
复制标题
基于空间组织的无酶核酸电路的相互切换
DOI：
10.1039/c6cc07153h
复制
发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Li, Bingling
中科院分区：
文献类型：
--
作者：
Tang, Yidan;Zhu, Zhentong;Li, Bingling
本文报道了一种基于空间组织的智能设计的新型核酸传感策略，该策略基于催化发夹组装（CHA）的互易开关。所谓的SORS-CHA不仅使设计良好的CHA电路成为任何目标序列的相对通用检测器，而且还保证了大大提高的信号分辨率和可信度，以最大限度地减少意外信号漂移引起的误读。有了更可靠的结果，但更简单的序列设计，核酸电路可能在现实世界的应用中具有竞争力。
We report a new nucleic acid sensing strategy through an intelligent design of spatial organization based reciprocal switching of catalytic hairpin assembly (CHA). The so-called SORS-CHA not only turns a well-designed CHA circuit into a relatively universal detector for any targeting sequence, but also guarantees a much enhanced signal resolution and a believability to minimize the misreading induced by unexpected signal drifts. Withmore trustworthy results, but a simpler sequence design, nucleic acid circuits could become competitive in real-world applications.