The effect of depression on quality of life of patients with type II diabetes mellitus
The effect of depression on quality of life of patients with type II diabetes mellitus
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DOI：
10.1002/da.20288
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发表时间：
2008-01-01
影响因子：
7.4
通讯作者：
Sahin, Mehmet
中科院分区：
文献类型：
--
作者：
Eren, Ibrahim;Erdi, Oezlem;Sahin, Mehmet
糖尿病（Diabetes mellitus，DM）是一种常见的慢性代谢性疾病，在其病程中伴随着多种并发症，严重影响患者的生活质量。据报道，糖尿病患者抑郁症的发病率较高，糖尿病是抑郁症发生的危险因素之一。据报道，共病精神障碍导致糖尿病患者生活质量进一步恶化。本研究旨在探讨抑郁对2型糖尿病患者生活质量的影响。根据DSM-IV标准诊断为当前重度抑郁发作的60例患者（30例女性和30例男性）和48例无重度抑郁发作的II型糖尿病患者（30例女性和18例男性）（非抑郁组）被纳入本研究。采用半结构式访谈表、汉密尔顿焦虑量表（HRSA）、汉密尔顿抑郁量表（HRSD）和土耳其版世界卫生组织生活质量评估简表（WHOQOL-BREF）评估患者的临床特征。抑郁组的HRSD和HRSA评分分别为24.87 +/- 4.83和21.07 +/- 5.44，而非抑郁组分别为7.83 +/- 3.92和6.88 +/- 3.43。抑郁组的躯体健康、心理健康、社会关系、环境和社会压力领域、一般健康相关生活质量、总体生活质量和WOQOL-BREF总分均显著低于非抑郁组。HRSD和HRSA评分与躯体健康、心理健康、社会关系、环境和社会压力领域、一般健康相关生活质量、总体生活质量和WHOQOL-BREF总分呈显著负相关。此外，HbA 1c水平与身体健康、社会关系、环境领域、社会压力领域、一般健康相关生活质量、总体生活质量和WHOQOL-BREF总分呈显著负相关。受教育程度与躯体健康、心理健康、社会关系、环境社会压力领域、总体生活质量、WHOQOL-BREF总分呈显著正相关。社会关系领域得分与年龄、病程呈显著负相关。我们的研究表明，II型糖尿病中抑郁症的存在进一步恶化了患者的生活质量。由于治疗抑郁症会对生活质量产生有益的影响，临床医生应仔细评估与II型糖尿病相关的抑郁症。
Diabetes mellitus (DM) is a frequently encountered metabolic disease with chronic features and involves numerous complications throughout its course, which causes severe restriction and disability in an individual's life. It has been reported that the incidence of depression is higher in diabetic patients and that diabetes is one of the risk factors in the development of depression. It has also been reported that co-morbid psychiatric disorders cause further deterioration in the quality of life in diabetic patients. The aim of this study was to investigate the effects of depression on the quality of life in type II DM patients. Sixty patients (30 females and 30 males) with current major depressive episode diagnosed according to DSM-IV criteria, and 48 type II DM patients (30 females and 18 males) without a major depressive episode (non-depressed group) were included in the study. All patients were evaluated with a semi-structured interview form to assess the clinical features of DM, Hamilton Rating Scale for Anxiety (HRSA), Hamilton Rating Scale for Depression (HRSD), and the Turkish version of The World Health Organization Quality of Life Assessment-Brief (WHOQOL-BREF). The HRSD and HRSA scores in the depressed group were 24.87 +/- 4.83 and 21.07 +/- 5.44, respectively, whereas those in the non-depressed group were 7.83 +/- 3.92 and 6.88 +/- 3.43, respectively. The physical health, psychological health, social relationship, environmental and social pressure domain, general health-related quality of life, overall quality of life, and WOQOL-BREF total scores were found significantly lower in the depressed group than the non-depressed group. There were significant negative correlations between HRSD and HRSA scores and physical health, psychological health, social relationship, environmental and social pressure domain, general health-related quality of life, overall quality of life, and WHOQOL-BREF total scores. Furthermore, there were significant negative correlations between the HbA1c level and physical health, social relationship, environmental domain, social pressure domain, general health-related quality of life, overall quality of life, and WHOQOL-BREF total scores. However, there was a significant positive correlation between the level of education and physical health, psychological health, social relationship, environmental social pressure domain, overall quality of life, and WHOQOL-BREF total scores. There were significant negative correlations between social relationship domain score, and age and duration of illness. Our study demonstrates that the presence of depression in type II DM further deteriorates the quality of life of the patients. Since treating depression would have a beneficial effect on the quality of life, clinicians should carefully assess for depression associated with type II DM.