On the mechanism of titanium-catalyzed cyclopropanation of esters with aliphatic organomagnesium compounds.: Deuterium distribution in the reaction products of (CD3)2CHMgBr with ethyl 3-chloropropionate in the presence of titanium tetraisopropoxide
On the mechanism of titanium-catalyzed cyclopropanation of esters with aliphatic organomagnesium compounds.: Deuterium distribution in the reaction products of (CD3)2CHMgBr with ethyl 3-chloropropionate in the presence of titanium tetraisopropoxide
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DOI：
10.1007/bf02494693
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发表时间：
2000-02-01
影响因子：
1.7
通讯作者：
Kulinkovich, OG
中科院分区：
文献类型：
--
作者：
Epstein, OL;Savchenko, AI;Kulinkovich, OG
在催化量的Ti（OPri）（4）存在下，（CD 3）（2）CHMgBr与3-氯丙酸乙酯反应产生（E）-1-（2-氯乙基）-3，3-二氘代-2-三氘代甲基环丙醇和（CD 3）（2）CDH，通过质谱鉴定。讨论了反应机理。
The reaction of (CD3)(2)CHMgBr with ethyl 3-chloropropionate in the presence of catalytic amounts of Ti(OPri)(4) results in (E)-1-(2-chloroethyl)-3,3-dideuterio-2-trideuteriomethylcyclopropanol and (CD3)(2)CDH, identified by mass spectrometry. The reaction mechanism is discussed.