Alginate-Based Biomaterials for Regenerative Medicine Applications.
Alginate-Based Biomaterials for Regenerative Medicine Applications.
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用于再生医学应用的海藻酸盐生物材料
DOI：
10.3390/ma6041285
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发表时间：
2013-03-26
期刊：
影响因子：
--
通讯作者：
Tan H
中科院分区：
文献类型：
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作者：
Sun J;Tan H
海藻酸盐是一种天然多糖，具有优异的生物相容性和生物降解性，在生物医学领域具有许多不同的应用。海藻酸盐易于加工用于适用的三维支架材料，例如水凝胶、微球、微胶囊、海绵、泡沫和纤维。基于藻酸盐的生物材料可用作组织工程的药物输送系统和细胞载体。海藻酸盐可以很容易地通过化学和物理反应进行修饰，以获得具有各种结构、性质、功能和应用的衍生物。通过与其他生物材料的结合、肽和糖分子等特定配体的固定以及物理或化学交联，可以实现结构和性质的调整，例如生物降解性、机械强度、凝胶性质和细胞亲和力。本综述重点介绍海藻酸盐及其衍生物在生物医学应用领域的最新进展，包括伤口愈合、软骨修复、骨再生和药物输送，这些在组织再生应用中具有潜力。
Alginate is a natural polysaccharide exhibiting excellent biocompatibility and biodegradability, having many different applications in the field of biomedicine. Alginate is readily processable for applicable three-dimensional scaffolding materials such as hydrogels, microspheres, microcapsules, sponges, foams and fibers. Alginate-based biomaterials can be utilized as drug delivery systems and cell carriers for tissue engineering. Alginate can be easily modified via chemical and physical reactions to obtain derivatives having various structures, properties, functions and applications. Tuning the structure and properties such as biodegradability, mechanical strength, gelation property and cell affinity can be achieved through combination with other biomaterials, immobilization of specific ligands such as peptide and sugar molecules, and physical or chemical crosslinking. This review focuses on recent advances in the use of alginate and its derivatives in the field of biomedical applications, including wound healing, cartilage repair, bone regeneration and drug delivery, which have potential in tissue regeneration applications.