A Single-Trial Estimation of the Feedback-Related Negativity and Its Relation to BOLD Responses in a Time-Estimation Task
A Single-Trial Estimation of the Feedback-Related Negativity and Its Relation to BOLD Responses in a Time-Estimation Task
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DOI：
10.1523/jneurosci.3684-13.2014
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发表时间：
2014-02-19
影响因子：
5.3
通讯作者：
Straube, Thomas
中科院分区：
文献类型：
--
作者：
Becker, Michael P. I.;Nitsch, Alexander M.;Straube, Thomas
事件相关电位（ERP）与反馈处理可靠相关，并在人类中得到充分研究的成分是反馈相关负波（FRN），它被认为表明中扣带皮层（MCC）神经元的激活。然而，最近的方法已经概念化这个额中枢ERP组件，至少部分地反映了奖励相关的大脑区域的激活与奖励的积极性，与功能磁共振成像研究调查反馈处理的背景下，奖励评价。发现收敛的电生理和BOLD反应引起的性能反馈，我们同时记录EEG和功能磁共振成像在时间估计任务。负反馈的ERP负幅值相对多于正反馈。传统的功能磁共振成像数据分析显示，激活的一些领域，包括腹侧纹状体，前扣带皮层，内侧前额叶皮层的积极与消极的反馈。最重要的是，当使用电生理反馈信号的单次试验幅度来估计血流动力学反应时，我们发现腹侧纹状体、中扣带回和中额叶皮质中的反馈相关BOLD反应对与反馈信号相关的正反馈而非负反馈在FRN的时间范围内。具体来说，这些区域的激活随着振幅变得更加积极而增加。这些研究结果表明，在时间估计任务中，奖励引起的积极性与几个奖励相关的大脑区域的大脑激活相关，并在FRN的时间范围内驱动不同的ERP反应。
An event-related potential (ERP) component reliably associated with feedback processing and well studied in humans is the feedback-related negativity (FRN), which is assumed to indicate activation of midcingulate cortex (MCC) neurons. However, recent approaches have conceptualized this frontocentral ERP component as reflecting at least partially a reward positivity associated with activation in reward-related brain regions, in line with fMRI studies investigating feedback processing in the context of reward evaluation. To discover convergence of electrophysiological and BOLD responses elicited by performance feedback, we concurrently recorded EEG and fMRI during a time-estimation task. The ERP showed relatively more negative amplitudes to negative than to positive feedback. Conventional analyses of fMRI data revealed activation of a number of areas, including ventral striatum, anterior cingulate cortex, and medial prefrontal cortex to positive versus negative feedback. Most importantly, when using single-trial amplitudes of electrophysiological feedback signals to estimate hemodynamic responses, we found feedback-related BOLD-responses in ventral striatum, midcingulate, and midfrontal cortices to positive but not to negative feedback associated with feedback signals in the time range of the FRN. Specifically, activation in these areas increased as amplitudes became more positive. These findings suggest that, in the time-estimation task, a positivity elicited by reward is associated with brain activation in several reward-related brain regions and is driving differential ERP responses in the time range of the FRN.