Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction
Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction
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DOI：
10.1089/scd.2011.0279
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发表时间：
2011-12-01
影响因子：
4
通讯作者：
Matsuyama, Tomohiro
中科院分区：
文献类型：
--
作者：
Nakagomi, Takayuki;Molnar, Zoltan;Matsuyama, Tomohiro
越来越多的证据表明，缺血性脑卒中后，神经干/祖细胞（NSPCs）可在非常规神经源性区域（如皮质）被激活。然而，缺血诱导的NSPCs（iNSPCs）的确切起源，身份和亚型，这可能有助于皮层神经发生，目前仍不清楚。在我们目前的研究中，使用成年小鼠皮质梗死模型，我们发现软脑膜（软脑膜），这是广泛分布在血管内，并密切相关的微血管周细胞/血管周围细胞在整个中枢神经系统（CNS），有NSPC活动，在响应缺血，并能产生神经元。这些观察结果表明，微血管周细胞驻留在从软脑膜分布到皮质的血管附近，是皮质梗死后神经发生的iNSPC的潜在来源。此外，我们的研究结果提出了一个新的概念，软脑膜，其中覆盖整个大脑，有一个重要的作用，中枢神经系统恢复脑损伤，如中风。
Increasing evidence shows that neural stem/ progenitor cells (NSPCs) can be activated in the nonconventional neurogenic zones such as the cortex following ischemic stroke. However, the precise origin, identity, and subtypes of the ischemia-induced NSPCs (iNSPCs), which can contribute to cortical neurogenesis, is currently still unclear. In our present study, using an adult mouse cortical infarction model, we found that the leptomeninges (pia mater), which is widely distributed within and closely associated with blood vessels as microvascular pericytes/perivascular cells throughout central nervous system (CNS), have NSPC activity in response to ischemia and can generate neurons. These observations indicate that microvascular pericytes residing near blood vessels that are distributed from the leptomeninges to the cortex are potential sources of iNSPCs for neurogenesis following cortical infarction. In addition, our results propose a novel concept that the leptomeninges, which cover the entire brain, have an important role in CNS restoration following brain injury such as stroke.