Robustness of bidirectional microtubule network self-organization
Robustness of bidirectional microtubule network self-organization
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DOI：
10.1101/825786
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发表时间：
2019-10
期刊：
影响因子：
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通讯作者：
A. Z. Płochocka;A. Davie;N. Bulgakova;L. Chumakova
中科院分区：
文献类型：
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作者：
A. Z. Płochocka;A. Davie;N. Bulgakova;L. Chumakova
生物系统的健壮性对于它们的生存至关重要，然而，对于许多系统来说，它的起源是一个悬而未决的问题。在这里，我们分析一个亚细胞水平的系统，微管细胞骨架。微管自组织成一个网络，沿着这个网络，细胞成分被运送到它们的生物相关位置。虽然个体微管是高度动态的，它们的动态依赖于有机体环境和遗传学，但网络对这种动态的敏感性将导致病理。结合果蝇的数学模型和遗传操作，我们证明了微管的自组织确实不依赖于单个微管的动力学，因此在组织水平上是健壮的。我们通过一个数学模型论证了这种稳健性的起源，表明这是一种通用的机制。
Robustness of biological systems is crucial for their survival, however, for many systems its origin is an open question. Here we analyze one sub-cellular level system, the microtubule cytoskeleton. Microtubules self-organize into a network, along which cellular components are delivered to their biologically relevant locations. While individual microtubule are highly dynamic with their dynamics depends on the organism environment and genetics, network sensitivity to this dynamics would result in pathologies. Combining mathematical modelling with genetic manipulations in Drosophila, we show that the microtubule self-organization indeed does not depend on dynamics of individual microtubules, and thus is robust on the tissue level. We demonstrate the origin of this robustness via a mathematical model, suggesting this being a generic mechanism.