Emerging medical therapies for severe alcoholic hepatitis.
Emerging medical therapies for severe alcoholic hepatitis.
复制标题
DOI：
10.3350/cmh.2020.0145
复制
发表时间：
2020-10
影响因子：
8.9
通讯作者：
Szabo G
中科院分区：
文献类型：
--
作者：
Tornai D;Szabo G
Severe alcoholic hepatitis (AH) is an acute and often devastating form of alcohol-associated liver disease. Clinically, AH is characterized by elevated bilirubin, model for end stage liver disease scores >20, and nonspecific symptoms that are caused by underlying inflammation, hepatocyte injury, and impaired intestinal barrier function. Compromised immune defense in AH contributes to infections, sepsis and organ failure. To date, corticosteroids are the only recommended treatment for severe AH, however it does not provide survival benefits beyond 1 month. Recent preclinical and early clinical studies in AH aided understanding of the disease and presented opportunities for new therapeutic options targeting inflammation, oxidative stress, liver regeneration and modification of intestinal microbiota. In this comprehensive review, we discuss promising preclinical results and ongoing clinical trials evaluating novel therapeutic agents for the treatment of severe AH.
登录
查看更多内容
CCR2/5信号的药理抑制可防止和逆转小鼠酒精诱导的肝损伤，脂肪变性和炎症。
DOI：
10.1002/hep.30249
发表时间：
2019-03
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Ambade A;Lowe P;Kodys K;Catalano D;Gyongyosi B;Cho Y;Iracheta-Vellve A;Adejumo A;Saha B;Calenda C;Mehta J;Lefebvre E;Vig P;Szabo G
通讯作者：
Szabo G
影响因子：
12.6
作者：
Frenette, Catherine T.;Morelli, Giuseppe;Hagerty, David T.
通讯作者：
Hagerty, David T.
影响因子：
4.2
作者：
Flamm, Steven L
通讯作者：
Flamm, Steven L
DOI：
10.1097/meg.0000000000000458
发表时间：
2015-11-01
影响因子：
2.1
作者：
Han, Sang Hak;Suk, Ki Tae;Kim, Eun Ji
通讯作者：
Kim, Eun Ji
影响因子：
25.7
作者：
Bird, GLA;Prach, AT;Danesh, BJ
通讯作者：
Danesh, BJ