Neuropeptide and serotonin immunoreactive neurons in the cat ventrolateral medulla
Neuropeptide and serotonin immunoreactive neurons in the cat ventrolateral medulla
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猫腹外侧延髓中的神经肽和血清素免疫反应神经元
DOI：
10.1016/0006-8993(88)91158-4
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
T. L. Krukoff
中科院分区：
文献类型：
--
作者：
J. Ciriello;M. M. Caverson;F. Calaresu;T. L. Krukoff
用免疫组织化学方法研究了猫延髓腹外侧区注射秋水仙碱后，5-羟色胺(5-羟色胺)、P物质(SP)、神经降压素(NT)和生长抑素(SS)样免疫反应阳性细胞体的分布。5-羟色胺、SP-IR、NT-IR和SS-IR的胞膜分布于VLM吻尾侧。虽然含有不同神经活性物质的神经元在VLM内的分布似乎是重叠的，但也观察到了一些明显的差异。在VLM尾侧，观察到的免疫反应阳性胞体大多含有5-羟色胺-IR。这些神经元主要分布在舌下神经出髓内根周围的内侧至外侧网状核(LRN)区域(12N)。在VLm的中间区域，主要在延髓腹外侧面的12N出根周围区域观察到含有5-羟色胺和SP-IR的核膜。相反，大多数含有NT-和SS-IR的细胞一直位于延髓网状结构中紧靠5-羟色胺和SP-IR核膜背侧的区域。最后，大多数免疫反应阳性的核膜位于VLM的吻侧，5-羟色胺和SP-IR的核膜分布于延髓腹外侧面附近的巨细胞旁外侧核(PGL)。这些数据表明，对5-羟色胺或几种不同神经肽有免疫反应的神经元位于VLm的区域，这些区域以前被认为与动脉血压的控制有关。由于VLM中含有这些神经活性物质的区域已被证明与脊髓交感神经区有直接联系，这些VLM细胞可能是参与控制循环的动态平衡机制的神经元回路的组成部分。
The distribution of cell bodies containing serotonin (5-HT)-, substance-P (SP)-, neurotensin (NT)-, and somatostatin (SS)-like immunoreactivity (IR) in ventrolateral medulla (VLM) of the cat was studied immunohistochemically after administration of colchicine into the cisterna magna. Perikarya containing 5-HT-, SP-, NT- or SS-IR were found throughout the rostrocaudal extent of the VLM. Although neurons containing the different neuroactive substances appeared to have an overlapping distribution in VLM, some distinct differences were observed. In the caudal VLM most of the immunoreactive cell bodies observed contained 5-HT-IR. These neurons were found primarily in the region medial to lateral reticular nucleus (LRN) around the exiting intramedullary rootlets of the hypoglossal nerve (12N). In the intermediate region of VLM, perikarya containing 5-HT- and SP-IR were observed primarily near the ventrolateral surface of the medulla in the region around the exiting rootlets of the 12N. In contrast, most of the cells containing NT- and SS-IR were consistently observed to occupy a region in the medullary reticular formation immediately dorsal to what where 5-HT- and SP-IR perikarya were found. Finally, most of the immunoreactive perikarya were found in the rostral VLM; perikarya containing 5-HT- and SP-IR were observed throughout the nucleus paragigantocellularis lateralis (PGL) near the ventrolateral surface of the medulla. These data indicate that neurons immunoreactive to either 5-HT or several different neuropeptides were located in regions of VLM which have previously been implicated in the control of arterial pressure. As regions of VLM containing these neuroactive substances in neuronal perikarya have been shown to have direct connections with spinal sympathetic areas it is likely that these VLM cells are components of neuronal circuits involved in homeostatic mechanisms controlling the circulation.
猫腹侧髓质 P 物质和单胺细胞的拓扑结构。
DOI：
10.1016/0165-1838(85)90116-x
发表时间：
1985
期刊：
Journal of the autonomic nervous system
影响因子：
--
作者：
Marson,L;Loewy,AD
通讯作者：
Loewy,AD
猫中缝背核中的脑啡肽免疫反应性核周体。
影响因子：
2.5
作者：
Moss,MS;Glazer,EJ;Basbaum,AI
通讯作者：
Basbaum,AI