Changes in transepidermal water loss and cutaneous blood flow during the menstrual cycle
Changes in transepidermal water loss and cutaneous blood flow during the menstrual cycle
复制标题
月经周期中经皮失水量和皮肤血流量的变化
作者：
J. Haryell;I. Hussona;I. Maibach
这项研究量化了正常女性在月经周期中的刺激敏感性和血管反应性。通过观察在月经周期的下列日期局部应用烟酸甲酯（MN）的血管舒张作用来研究这种变化：（i）推定的最大雌激素分泌日，（ii）最大孕酮分泌日，（iii）最大孕酮分泌日，（iv）最大孕酮分泌日，（iv）最大孕酮分泌日。（iii）雌激素孕酮分泌最少的当天，这些反应通过以下剂量反应特征的变化来证明：初始反应（IR），峰响应（PR）和曲线下面积（AUC）。基线激光多普勒血流仪（LDV）的血流值和经表皮水分损失（TEWK）值米正常皮肤也获得。当3个检测日的数值相互比较时，任何剂量反应特征（IR、PR、AUC）均不存在显著差异，基线TEWL确实存在显著差异。当比较最大雌激素分泌日与最小雌激素/孕酮分泌日时的值。在背部（p= 0.037）和前臂（p= 0.021）部位，与最大雌激素分泌日相比，最小雌激素/孕激素分泌日的TEWL更高，表明与排卵前相比，月经开始前的皮肤屏障分泌较不完全。与最大孕酮分泌日相比，最大雌激素分泌日的基线血流量也存在显著差异，在最大孕酮分泌日，在晒（p= 0.021）和前臂（p= 0.009）部位记录到较高的基线血流量。
This study quantified irritant susceptibility and blood vessel reactivity in normal women over the course of the menstrual cyele. Such alterations were studied by observing vasodilation from topical application of methyl methyl nieotinate (MN) on the following days of the menstrual cycle: (i) the day of putative maximal estrogen secretion; (ii) the Jay of maximal progesterone secretion; (iii) the day of minimal estrogen progesterone secretion, These responses were evidenced by changes in the following dose response characteristics the initial response (IR), the peak response (PR) and the area under the curve (AUC). Baseline laser Doppler Velocimetry (LDV) blood flow values and transepidermal water loss (TEWK) values mi normal skin were also obtained. No Significant differences existed for any of the dose‐response characteristics (IR. PR. AUC) when the values for the 3 testing days were compared to one another Significant differences did exist for baseline TEWL. values when comparing the day maximal estrogen secretion to the day of minimal estrogen/progesterone Secretion. TEWL was higher on the day of minimal estrogen/progesterone secretion aS compared to the day of maximal estrogen secretion on both back (p= 0.0.037) and forearm (p= 0.021) Sites, suggesting that the skin barrier secretion is less complete on the days just prior to the onset of the menses as Compared to the days just prior to the Ovulation. Significant differences in baseline blood flow also existed, for the day of maximal estrogen secretion as compared to the day Of maximal progesterone secretion, with higher baseline blood flow recorded on the day of maximal progesterone secretion on both the bask (p= 0.021) and forearm (p= 0.009)sites.