Substrate- and antibiotic-binding sites at the peptidyl-transferase centre of Escherichia coli ribosomes. Studies on the chloramphenicol. lincomycin and erythromycin sites.
Substrate- and antibiotic-binding sites at the peptidyl-transferase centre of Escherichia coli ribosomes. Studies on the chloramphenicol. lincomycin and erythromycin sites.
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大肠杆菌核糖体肽基转移酶中心的底物和抗生素结合位点。
DOI：
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发表时间：
1971
期刊：
影响因子：
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通讯作者：
Ramon Torres‐Pinedo
中科院分区：
文献类型：
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作者：
Rafael Fernández;Robin E. Monro;David Vázquez;Ramon Torres‐Pinedo
在大肠杆菌中，林可霉素、氯霉素和红霉素的每个核糖体都有一个结合位点。
这些抗生素作用于50-S亚基上密切相关的部位。然而，这三个位点的性质有一些有趣的差异，例如：(A)明显有可能在不关闭氯霉素位点的情况下阻止林可霉素位点，(B)氯霉素和红霉素之间竞争效应的不对称性，(C)对乙醇的不同反应，以及(D)对其他抗生素(嘌罗霉素、大环内酯类、链球菌A和B以及其他作用于较大核糖体亚单位的抗生素)的不同反应。
In Escherichia coli there is one binding site per ribosome for lincomycin, chloramphenicol and erythromycin.
These antibiotics act at closely related sites on the 50-S subunit. There are, however, some interesting differences in the properties of the three sites, such as: (a) the apparent possibility of obstructing the lincomycin site without closing the chloramphenicol site, (b) asymmetry of competition effects between chloramphenicol and erythromycin, (c) differential responses to ethanol and (d) differential responses to other antibiotics (puromycin, macrolides, streptogramins A and B and others also acting on the larger ribosome subunit).