The Role of Peripheral Inflammatory Markers in Dementia and Alzheimer's Disease: A Meta-Analysis
The Role of Peripheral Inflammatory Markers in Dementia and Alzheimer's Disease: A Meta-Analysis
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DOI：
10.1093/gerona/gls187
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发表时间：
2013-04-01
影响因子：
5.1
通讯作者：
Yaffe, Kristine
中科院分区：
文献类型：
--
作者：
Koyama, Alain;O'Brien, Jacqueline;Yaffe, Kristine
研究炎症标志物与痴呆风险之间关系的研究相互矛盾。因此，研究人员对观察性研究进行了系统回顾和荟萃分析，假设外周促炎标志物水平升高与全因痴呆或阿尔茨海默病（AD）的风险相关。研究人员对PubMed和PsycInfo数据库中索引的观察性研究进行了文献检索。选定的研究包括那些至少有一种外周炎症生物标志物及其与全因痴呆或AD风险相关的研究。使用随机效应模型生成合并的风险比（HR），比较炎症标志物水平的上分位数与下分位数。使用I-2统计量评估了异质性，确定了7项研究，共5，717名参与者，746例全因痴呆和565例AD。C反应蛋白水平升高与全因痴呆风险增加45%相关（HR：1.45; 95% CI：1.10，1.91）。同样，较高水平的白细胞介素-6与全因痴呆的风险增加32%（HR：1.32; 95% CI：1.06，1.64）相关。对于单独的AD，与C反应蛋白的相关性不太明显（HR：1.21; 95% CI：1.03，1.42），白细胞介素-6与AD风险无关（HR：1.06; 95% CI：0.83，1.35）。在任何荟萃分析中均未发现显著异质性（I-2 = 0%~ 40%，第16页）。外周炎症标记物水平升高与全因痴呆风险适度增加相关。仅与AD风险相关的证据有限。
Studies that have investigated the association between markers of inflammation and risk of dementia are conflicting. Therefore, the researchers conducted a systematic review and meta-analysis of observational studies with the hypothesis that an increased level of peripheral proinflammatory markers would be associated with risk of all-cause dementia or Alzheimers disease (AD).The researchers conducted a literature search of observational studies indexed in the PubMed and PsycInfo databases. Selected studies included those with at least one peripheral inflammatory biomarker and its association with risk of all-cause dementia or AD. Random effects models were used to generate pooled hazard ratios (HRs) comparing the top versus bottom quantile of inflammatory marker level. Heterogeneity was assessed using the I-2 statistic.Seven studies were identified, combining for a total 5,717 participants, 746 cases of all-cause dementia and 565 cases of AD. An increased level of C-reactive protein was associated with a 45% increased risk of all-cause dementia (HR: 1.45; 95% CI: 1.10, 1.91). Similarly, a higher level of interleukin-6 was associated with a 32% increased risk (HR: 1.32; 95% CI: 1.06, 1.64) of all-cause dementia. For AD alone, the association with C-reactive protein was less pronounced (HR: 1.21; 95% CI: 1.03, 1.42) and interleukin-6 was not associated with risk of AD (HR: 1.06; 95% CI: 0.83, 1.35). No significant heterogeneity was found in any of the meta-analyses (I-2 = 0%40%, p .16).An increased peripheral level of inflammatory markers is associated with a modest increase in risk of all-cause dementia. Evidence for an association with risk of AD alone is limited.