Synthetic Biology Open Language (SBOL) Version 2.2.0.
Synthetic Biology Open Language (SBOL) Version 2.2.0.
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DOI：
10.1515/jib-2018-0001
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发表时间：
2018-04-02
影响因子：
1.9
通讯作者：
Wipat A
中科院分区：
文献类型：
--
作者：
Cox RS;Madsen C;McLaughlin JA;Nguyen T;Roehner N;Bartley B;Beal J;Bissell M;Choi K;Clancy K;Grünberg R;Macklin C;Misirli G;Oberortner E;Pocock M;Samineni M;Zhang M;Zhang Z;Zundel Z;Gennari JH;Myers C;Sauro H;Wipat A
合成生物学建立在遗传学，分子生物学和代谢工程的技术和成功的基础上，通过将工程原理应用于生物系统的设计。该领域仍然面临着巨大的挑战，包括开发时间长，失败率高，可重复性差。改善这些问题的一种方法是改善实验室之间有关设计系统的信息交流。合成生物学开放语言（SBOL）已被开发为标准，以支持合成生物学中生物设计信息的规范和交换，填补了其他现有标准无法满足的需求。本文档详细介绍了SBOL的2.2.0版本，该版本基于去年JIB特刊中发布的2.1.0版本。特别是，SBOL 2.2.0包括改进的遗传设计出处的描述和验证规则，支持组合遗传设计的扩展，添加非SBOL数据作为附件的新类，遗传设计实现的新类，以及描述SBOL数据模型中整个设计-构建-测试-学习周期的方法描述。
Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long development times, high rates of failure, and poor reproducibility. One method to ameliorate these problems would be to improve the exchange of information about designed systems between laboratories. The synthetic biology open language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing standards. This document details version 2.2.0 of SBOL that builds upon version 2.1.0 published in last year’s JIB special issue. In particular, SBOL 2.2.0 includes improved description and validation rules for genetic design provenance, an extension to support combinatorial genetic designs, a new class to add non-SBOL data as attachments, a new class for genetic design implementations, and a description of a methodology to describe the entire design-build-test-learn cycle within the SBOL data model.