Combining regenerative medicine strategies to provide durable reconstructive options: auricular cartilage tissue engineering.
Combining regenerative medicine strategies to provide durable reconstructive options: auricular cartilage tissue engineering.
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DOI：
10.1186/s13287-015-0273-0
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发表时间：
2016-01-28
影响因子：
7.5
通讯作者：
Whitaker IS
中科院分区：
文献类型：
--
作者：
Jessop ZM;Javed M;Otto IA;Combellack EJ;Morgan S;Breugem CC;Archer CW;Khan IM;Lineaweaver WC;Kon M;Malda J;Whitaker IS
再生医学的最新进展使我们在提高工程组织质量方面处于独特的地位。我们以耳廓软骨为样本，说明组织特异性成人干细胞的使用、通过添加剂制造进行组装以及对出生后组织成熟的更好理解将如何使我们能够更准确地复制自然组织的各向异性。本文着重介绍了自体耳廓重建术的局限性，包括供体部位的发病率、技术问题和长期并发症。目前已观察到植入免疫活性动物模型的组织工程耳廓结构会经历炎症、纤维化、异物反应、钙化和降解。结合仿生再生医学策略将使我们能够在生化组成和功能以及微观结构组织和整体形状方面改进组织工程耳软骨。创造功能和耐用的组织有可能通过消除对供体部位的需求来改变重建外科的范式。
Recent advances in regenerative medicine place us in a unique position to improve the quality of engineered tissue. We use auricular cartilage as an exemplar to illustrate how the use of tissue-specific adult stem cells, assembly through additive manufacturing and improved understanding of postnatal tissue maturation will allow us to more accurately replicate native tissue anisotropy. This review highlights the limitations of autologous auricular reconstruction, including donor site morbidity, technical considerations and long-term complications. Current tissue-engineered auricular constructs implanted into immune-competent animal models have been observed to undergo inflammation, fibrosis, foreign body reaction, calcification and degradation. Combining biomimetic regenerative medicine strategies will allow us to improve tissue-engineered auricular cartilage with respect to biochemical composition and functionality, as well as microstructural organization and overall shape. Creating functional and durable tissue has the potential to shift the paradigm in reconstructive surgery by obviating the need for donor sites.