Catalytic PtPd bimetal nanocrystals with high-index facets for radiation injury repair
Catalytic PtPd bimetal nanocrystals with high-index facets for radiation injury repair
复制标题
用于辐射损伤修复的高折射率晶面催化 PtPd 双金属纳米晶
DOI：
10.1016/j.cclet.2019.03.044
复制
发表时间：
2020-01-01
影响因子：
9.1
通讯作者：
Zhang, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Long, Wei;Wang, Jingya;Zhang, Xiao-Dong
Radiotherapy is one of the most important clinical cancer treatments, which works mainly by delivering a prescribed radiation dose to the tumor tissues. However, high doses of radiation may also lead many irreversible damages to the surrounding normal tissues. Thereby, how to effectively reduce these side-effects has been a significant factor in influencing cancer therapeutic effect. In this work, we synthesized the hollow PtPd nanocubes with high-index facets, and investigated the radiation protection capability in vitro and in vivo. Our results showed the PtPd nanocrystals can decrease the ROS level and improve the survival rate of radiated cells. Meanwhile, survival rate of radiated mice can significantly increase from 0 to 30% after PtPd treatment. Consequently, the enzyme and ROS level in radiated mice can be recovered. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
