Stimuli-Induced Core-Corona Inversion of Micelle of Poly(acrylic acid)-block-Poly(N-isopropylacrylamide) and Its Application in Drug Delivery
Stimuli-Induced Core-Corona Inversion of Micelle of Poly(acrylic acid)-block-Poly(N-isopropylacrylamide) and Its Application in Drug Delivery
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DOI：
10.1002/macp.201400440
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发表时间：
2015-02-02
影响因子：
2.5
通讯作者：
Yamauchi, Yusuke
中科院分区：
文献类型：
--
作者：
Bastakoti, Bishnu Prasad;Guragain, Sudhina;Yamauchi, Yusuke
Core-corona inversion of micelles of diblock copolymer poly(acrylic acid)-block-poly(N-isopropylacrylamide) (PAA-b-PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH-sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.
