Immunocytochemical identification of a relaxin-like protein in gastrointestinal epithelium and carcinoma: a preliminary report.
Immunocytochemical identification of a relaxin-like protein in gastrointestinal epithelium and carcinoma: a preliminary report.
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胃肠道上皮和癌中松弛素样蛋白的免疫细胞化学鉴定：初步报告。
作者：
G N Stemmermann;W. Mesiona;F C Greenwood;G. Bryant
用人松弛素（H2）抗体的免疫染色表明胃肠道及其肿瘤中存在松弛素样肽。该肽存在于细胞脱落部位的非肿瘤细胞的细胞质中：胃的表面细胞、小肠绒毛和结肠的表面细胞。它也发生在胃壁细胞和胃癌和结肠癌的细胞质中。松弛素已显示刺激胶原酶基因表达并下调人皮肤成纤维细胞中的胶原合成和分泌。这里显示的松弛素的分布表明，它可能在细胞周期结束时非肿瘤细胞从其基底膜上脱离以及癌细胞穿透基底膜中发挥作用。
Immunostaining with antibodies to human relaxin (H2) suggests the presence of a relaxin-like peptide in the gastrointestinal tract and its tumours. The peptide is present in the cytoplasm of non-neoplastic cells at sites of cell exfoliation: the surface cells of the stomach, the small intestinal villi and the surface cells of the colon. It also occurs in the cytoplasm of gastric parietal cells and carcinomas of both the stomach and the colon. Relaxin has been shown to stimulate collagenase gene expression and to down-modulate collagen synthesis and secretion in human skin fibroblasts. The distribution of relaxin shown here suggests that it could play a role in the detachment of non-neoplastic cells from their basement membranes at the end of the cell cycle and in the penetration of carcinoma cells through the basement membrane.