Manipulation of lipid bioaccessibility of almond seeds influences postprandial lipemia in healthy human subjects
Manipulation of lipid bioaccessibility of almond seeds influences postprandial lipemia in healthy human subjects
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DOI：
10.1093/ajcn/88.4.922
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发表时间：
2008-10-01
影响因子：
7.1
通讯作者：
Ellis, Peter R.
中科院分区：
文献类型：
--
作者：
Berry, Sarah E. E.;Tydeman, Elizabeth A.;Ellis, Peter R.
背景资料：已知植物细胞壁影响消化过程中植物食物组织中脂质释放的速率和程度，然而，细胞壁结构对餐后脂血症的影响尚不清楚。目的：探讨植物细胞壁结构对脂释放的影响通过比较由细胞壁包封的脂质与作为游离油存在的脂质，来评价对餐后脂血症的生物可及性。一项随机交叉试验（n = 20名男性）比较了含有54 g脂肪的3种膳食对氧化应激的餐后变化的影响，所述脂肪以全杏仁籽大颗粒（WA）、杏仁油和脱脂杏仁粉（AO）或作为对照的向日葵油混合物（CO）提供（8-异前列腺素F（2）α浓度），血管张力（外周增强指数）以及血浆三酰甘油、葡萄糖和胰岛素浓度。结果：血浆三酰甘油的餐后增加较低[曲线下面积（iAUC）增量降低74%和58%] WA餐后较AO餐和CO餐后有显著性差异（P < 0.001）。WA餐（iAUC：114; 95%CI：76，153）后血糖浓度（0-180 min）的增加显著高于AO餐（iAUC：74; 95%CI：48，99）（P < 0.05），但未观察到与CO餐的显著差异（iAUC：88; 95%CI：66，109）。WA、AO和CO餐后外周增强指数的峰值降低（2 h时分别为-9.5%、-10.1%和-12.6%）在餐间无显著差异。血浆8-异前列腺素F（2）α和胰岛素浓度没有显着差异之间的meals.Conclusions：杏仁种子中的脂质，这是由细胞壁的结构和性能调节的生物可及性，起着决定餐后脂血症的主要作用。
Background: Plant cell walls are known to influence the rate and extent of lipid release from plant food tissues during digestion; however, the effect of cell wall structure on postprandial lipemia is unknown.Objective: The objective was to investigate the effects of lipid release (bioaccessibility) on postprandial lipemia by comparing lipid encapsulated by cell walls with lipid present as free oil.Design: A randomized crossover trial (n = 20 men) compared the effects of 3 meals containing 54 g fat provided as whole almond seed macroparticles (WA), almond oil and defatted almond flour (AO), or a sunflower oil blend as control (CO) on postprandial changes in oxidative stress (8-isoprostane F(2)alpha concentrations), vascular tone (peripheral augmentation index), and plasma triacylglycerol, glucose, and insulin concentrations.Results: The postprandial increase in plasma triacylglycerol was lower [74% and 58% lower incremental area under curve (iAUC)] after the WA meal than after the AO and CO meals (P < 0.001). Increases in plasma glucose concentrations (0-180 min) were significantly higher after the WA meal (iAUC: 114; 95% CI: 76, 153) than after the AO meal (iAUC: 74; 95% CI: 48, 99) (P < 0.05), but no significant differences from the CO meal were observed (iAUC: 88; 95% CI: 66, 109). The peak reductions in peripheral augmentation index after the WA, AO, and CO meals (-9.5%, -10.1%, and -12.6%, respectively, at 2 h) were not significantly different between meals. Plasma 8-isoprostane F(2)alpha and insulin concentrations did not differ significantly between meals.Conclusions: The bioaccessibility of lipid in almond seeds, which is regulated by the structure and properties of cell walls, plays a primary role in determining postprandial lipemia.