Pulse-Echo Quantitative US Biomarkers for Liver Steatosis: Toward Technical Standardization.
Pulse-Echo Quantitative US Biomarkers for Liver Steatosis: Toward Technical Standardization.
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作者：
肝脏脂肪过多（脂肪变性）现在是全球慢性肝病最常见的原因，也是肝硬化和相关并发症的独立危险因素。准确和临床上有用的诊断、风险分层、诊断和治疗监测需要以可接受的成本进行准确和可靠的生物标志物测量。本文描述了美国医学超声研究所（AIUM）和RSNA定量成像生物标志物联盟（QIBA）的共同努力，以制定肝脏脂肪变性定量生物标志物的临床和技术验证标准。AIUM肝脏脂肪定量工作组提供临床指导，而RSNA QIBA脉冲回波定量超声生物标志物委员会开发测量生物标志物和减少生物标志物变异性的方法。在这篇文章中，作者介绍了肝脏脂肪变性定量成像生物标志物的临床需求，综述了各种成像方式的现状，并描述了三种关键的肝脏脂肪变性脉冲回波定量US生物标志物的技术现状：衰减系数，反向散射系数和声速。最后，提供了当前挑战的观点和每种生物标志物的临床翻译建议。标准化的技术性能和临床实施的脉冲回波定量超声是必不可少的，适合目的超声肝脏脂肪变性生物标志物的发展。
Excessive liver fat (steatosis) is now the most common cause of chronic liver disease worldwide and is an independent risk factor for cirrhosis and associated complications. Accurate and clinically useful diagnosis, risk stratification, prognostication, and therapy monitoring require accurate and reliable biomarker measurement at acceptable cost. This article describes a joint effort by the American Institute of Ultrasound in Medicine (AIUM) and the RSNA Quantitative Imaging Biomarkers Alliance (QIBA) to develop standards for clinical and technical validation of quantitative biomarkers for liver steatosis. The AIUM Liver Fat Quantification Task Force provides clinical guidance, while the RSNA QIBA Pulse-Echo Quantitative Ultrasound Biomarker Committee develops methods to measure biomarkers and reduce biomarker variability. In this article, the authors present the clinical need for quantitative imaging biomarkers of liver steatosis, review the current state of various imaging modalities, and describe the technical state of the art for three key liver steatosis pulse-echo quantitative US biomarkers: attenuation coefficient, backscatter coefficient, and speed of sound. Lastly, a perspective on current challenges and recommendations for clinical translation for each biomarker is offered. Standardization of technical performance and clinical implementation of pulse-echo quantitative US is essential for the development of fit-for-purpose sonographic liver steatosis biomarkers.
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DOI：
10.1002/hep.29797
发表时间：
2018-08
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Caussy C;Reeder SB;Sirlin CB;Loomba R
通讯作者：
Loomba R
影响因子：
19.7
作者：
Barr, Richard G.;Ferraioli, Giovanna;Levine, Deborah
通讯作者：
Levine, Deborah
影响因子：
4.5
作者：
Bashir, Mustafa R.;Horowitz, Jeanne M.;Carucci, Laura R.
通讯作者：
Carucci, Laura R.
影响因子：
29.4
作者：
Goldberg D;Ditah IC;Saeian K;Lalehzari M;Aronsohn A;Gorospe EC;Charlton M
通讯作者：
Charlton M
系统和传感器之间的功率谱一致性。
影响因子：
2.9
作者：
Guerrero QW;Fan L;Brunke S;Milkowski A;Rosado-Mendez IM;Hall TJ
通讯作者：
Hall TJ