Myeloma bone marrow acid phosphatase staining: a correlative study of 38 patients.
Myeloma bone marrow acid phosphatase staining: a correlative study of 38 patients.
复制标题
骨髓瘤骨髓酸性磷酸酶染色：38例患者的相关研究。
DOI：
10.1182/blood.v55.5.802.bloodjournal555802
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发表时间：
1980
期刊：
影响因子：
20.3
通讯作者：
S. Salmon
中科院分区：
文献类型：
--
作者：
R. Bataille;B. Durie;J. Sany;S. Salmon
本文对38例多发性骨髓瘤（MM）患者浆细胞酸性磷酸酶（AP）活性进行了研究。每个细胞的平均活性很强（平均评分= 2.42;最高评分= 4），超过71%的患者中阳性细胞的百分比大于90%。与复发（2.48 +/- 0.77）和缓解（1.81 +/- 1.02）相比，治疗前每个细胞的平均AP活性（3.06 +/- 0.53）更高（分别为p <0.05和p <0.01）。在研究时AP活性与临床特征的相关性中，唯一显著差异是κ和λ亚型之间。与kappa MM患者相比，λ MM患者在缓解期每个细胞的平均AP活性更高（2.71 +/- 0.43）（1.17 +/- 1.06，差异p <0.05）。AP活性与骨受累程度无显著相关性。然而，活动似乎是疾病活动的一个很好的标志。
Acid phosphatase (AP) activity of plasma cells was studied in 38 patients with multiple myeloma (MM). The average activity per cell was strong (mean score = 2.42; maximum score = 4) and the percentage of positive cells was greater than 90% in over 71% of patients. The average AP activity per cell was higher prior to treatment (3.06 +/- 0.53) compared to relapse (2.48 +/- 0.77) and remission (1.81 +/- 1.02 (p less than 0.05 and p less than 0.01, respectively). In correlation of AP activity with clinical features at the time of the study, the only significant difference was between kappa and lambda subtype. Patients with lambda MM had a higher average AP activity per cell in remission (2.71 +/- 0.43) as opposed to kappa MM (1.17 +/- 1.06, p less than 0.05 for difference). AP activity was not significantly correlated with degree of bone involvement. However, activity seemed to be a good marker of disease activity.