Near-infrared fluorescence tumor imaging using nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide
Near-infrared fluorescence tumor imaging using nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide
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DOI：
10.1016/j.biomaterials.2009.05.046
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发表时间：
2009-10-01
期刊：
影响因子：
14
通讯作者：
Kimura, Shunsaku
中科院分区：
文献类型：
--
作者：
Makino, Akira;Kizaka-Kondoh, Shinae;Kimura, Shunsaku
采用近红外荧光（NIRF）光学成像技术，研究了由聚L-乳酸-聚肌氨酸嵌段组成的纳米载体乳糖体（lactosome）作为肝肿瘤造影剂的成像特性。吲哚菁绿色（ICG）标记的乳糖体具有较强的逃逸网状内皮系统（RES）的能力。发现乳糖体在血液循环中稳定，并且在通过将HepG 2/EF-Luc细胞移植到小鼠肝脏获得的模型肝脏肿瘤部位特异性地逐渐积累。高的肿瘤/肝脏成像比率是由于乳糖体的增强的渗透和保留（EPR）效应。肿瘤部位的荧光强度与恶性程度相关。因此，使用乳糖体作为纳米载体的肿瘤成像是一种简便和通用的肿瘤成像技术的潜在候选者。(C)2009爱思唯尔有限公司保留所有权利。
A nanocarrier, lactosome, which is composed of poly(L-lactic acid)-block-poly(sarcosine), as a contrast agent for the liver tumor imaging was examined using the near infrared fluorescence (NIRF) optical imaging technique. Lactosome labeled with indocyanine green (ICG) showed a high escape ability from the reticulo-endothelial system (RES). Lactosome was found to be stable in a blood circulation, and gradually accumulated specifically at a model liver tumor site, which was obtained by graft of HepG2/EF-Luc cells at a mouse liver. The high tumor/liver imaging ratio is due to the enhanced permeation and retention (EPR) effect of lactosome. The fluorescence intensity at the tumor site was correlated with the degree of malignancy. Tumor imaging using lactosome as a nanocarrier is therefore a potential candidate for a facile and general tumor imaging technique. (C) 2009 Elsevier Ltd. All rights reserved.