Retrospective assessment of at-risk myocardium in reperfused acute myocardial infarction patients using contrast-enhanced balanced steady-state free-precession cardiovascular magnetic resonance at 3T with SPECT validation.
Retrospective assessment of at-risk myocardium in reperfused acute myocardial infarction patients using contrast-enhanced balanced steady-state free-precession cardiovascular magnetic resonance at 3T with SPECT validation.
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DOI：
10.1186/s12968-021-00730-7
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发表时间：
2021-03-15
期刊：
影响因子：
--
通讯作者：
Dharmakumar R
中科院分区：
文献类型：
--
作者：
Sun Z;Zhang Q;Zhao H;Yan C;Yang HJ;Li D;Li K;Liu Z;Yang Q;Dharmakumar R
对比增强（CE）稳态自由进动（SSFP） CMR在1.5T时已被证明是一种有价值的替代基于t2的方法，用于检测和定量急性心肌梗死（AMI）患者的危险区域（AAR）。然而，CE-SSFP在3T时评估AAR的能力尚未被调查。我们通过单光子发射计算机断层扫描（SPECT）验证验证了CE-SSFP和T2-STIR在3T时回顾性评估AAR的临床应用。在血运重建术后3 - 7天内，共招募60例AMI患者（st段抬高AMI， n = 44；非st段抬高AMI， n = 16）加入CMR研究。所有患者均接受T2-STIR、CE-bSSFP和晚期钆增强CMR检查。为了验证，在一组患者（n = 30）中获得SPECT图像。60例患者中有53例（88%）T2-STIR具有诊断质量，而60例患者中有54例（90%）CE-SSFP具有诊断质量。在头对头的每片比较（n = 365）中，使用T2-STIR和CE-SSFP量化的AAR没有差异（R2 = 0.92, p < 0.001；偏差：-0.4±0.8 cm2, p = 0.46）。在每位患者的基础上，CE-SSFP （n = 29）和SPECT （R2 = 0.86, p < 0.001；偏倚：−1.3±7.8% LV, p = 0.39）测定AAR有很好的一致性。T2-STIR与SPECT测量AAR的结果也吻合良好（R2 = 0.81, p < 0.001，偏倚：0.5±11.1% LV, p = 0.81）。在每位患者分析中，CE-SSFP和T2-STIR在评估AAR方面也有很强的一致性（R2 = 0.84, p < 0.001，偏倚：- 2.1±10.1% LV, p = 0.31）。在3T时，CE-SSFP和T2-STIR均可回顾性定量高危心肌，准确度较高。
Contrast-enhanced (CE) steady-state free precession (SSFP) CMR at 1.5T has been shown to be a valuable alternative to T2-based methods for the detection and quantifications of area-at-risk (AAR) in acute myocardial infarction (AMI) patients. However, CE-SSFP’s capacity for assessment of AAR at 3T has not been investigated. We examined the clinical utility of CE-SSFP and T2-STIR for the retrospective assessment of AAR at 3T with single-photon-emission-computed tomography (SPECT) validation. A total of 60 AMI patients (ST-elevation AMI, n = 44; non-ST-elevation AMI, n = 16) were recruited into the CMR study between 3 and 7 days post revascularization. All patients underwent T2-STIR, CE-bSSFP and late-gadolinium-enhancement CMR. For validation, SPECT images were acquired in a subgroup of patients (n = 30). In 53 of 60 patients (88 %), T2-STIR was of diagnostic quality compared with 54 of 60 (90 %) with CE-SSFP. In a head-to-head per-slice comparison (n = 365), there was no difference in AAR quantified using T2-STIR and CE-SSFP (R2 = 0.92, p < 0.001; bias:-0.4 ± 0.8 cm2, p = 0.46). On a per-patient basis, there was good agreement between CE-SSFP (n = 29) and SPECT (R2 = 0.86, p < 0.001; bias: − 1.3 ± 7.8 %LV, p = 0.39) for AAR determination. T2-STIR also showed good agreement with SPECT for AAR measurement (R2 = 0.81, p < 0.001, bias: 0.5 ± 11.1 %LV, p = 0.81). There was also a strong agreement between CE-SSFP and T2-STIR with respect to the assessment of AAR on per-patient analysis (R2 = 0.84, p < 0.001, bias: − 2.1 ± 10.1 %LV, p = 0.31). At 3T, both CE-SSFP and T2-STIR can retrospectively quantify the at-risk myocardium with high accuracy.
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影响因子：
37.8
作者：
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